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Girdler SS, Pedersen CA, Light KC Thyroid axis function during the menstrual cycle in women with premenstrual syndrome. Psychoneuroendocrinology. 1995;20(4):395-403.
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Grewen KM, Girdler SS, Hinderliter A, Light KC Depressive symptoms are related to higher ambulatory blood pressure in people with a family history of hypertension. Psychosom Med. 2004 Jan-Feb;66(1):9-16.
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Hinderliter AL, Light KC, Willis PW 4th Patients with borderline elevated blood pressure have enhanced left ventricular contractility. Am J Hypertens. 1995 Oct;8(10 Pt 1):1040-5.
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Light KC, Turner JR, Hinderliter AL, Sherwood A Race and gender comparisons: II. Predictions of work blood pressure from laboratory baseline and cardiovascular reactivity measures. Health Psychol. 1993 Sep;12(5):366-75.
Light KC, Turner JR, Hinderliter AL Job strain and ambulatory work blood pressure in healthy young men and women. Hypertension. 1992 Aug;20(2):214-8.
Light KC, Turner JR Stress-induced changes in the rate of sodium excretion in healthy black and white men. J Psychosom Res. 1992 Jul;36(5):497-508.
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Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
