Hypertension — Interactions Between Antihypertensive Drugs and Drugs Prescribed in the Emergency Room
Citation(s)
Amariles P, Giraldo NA, Faus MJ [Clinical relevance of drug interactions]. Med Clin (Barc). 2007 Jun 2;129(1):27-35. Review. Spanish.
Horn JR, Hansten PD, Chan LN Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. Epub 2007 Mar 27.
Iniesta-Navalón C, Urbieta-Sanz E, Gascón-Cánovas JJ [Analysis of the drug interactions associated to domiciliary drug therapy in elderly hospitalized patients]. Rev Clin Esp. 2011 Jul-Aug;211(7):344-51. doi: 10.1016/j.rce.2011.04.005. Epub 2011 Jun 2. Spanish.
Morales-Olivas FJ, Estañ L [Antihypertensive drug-drug interactions]. Med Clin (Barc). 2005 May 28;124(20):782-9. Review. Spanish.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
