Clinical trial NCT02024386 - References

Hypertension, Pulmonary — Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude

Citation(s)

•   Ahsan A, Charu R, Pasha MA, Norboo T, Charu R, Afrin F, Ahsan A, Baig MA
  eNOS allelic variants at the same locus associate with HAPE and adaptation. Thorax. 2004 Nov;59(11):1000-2.
•   Allen BW, Stamler JS, Piantadosi CA
  Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. Trends Mol Med. 2009 Oct;15(10):452-60. doi: 10.1016/j.molmed.2009.08.002. Epub 2009 Sep 24. Review.
•   Bärtsch P, Maggiorini M, Ritter M, Noti C, Vock P, Oelz O
  Prevention of high-altitude pulmonary edema by nifedipine. N Engl J Med. 1991 Oct 31;325(18):1284-9.
•   Beidleman BA, Muza SR, Fulco CS, Cymerman A, Ditzler D, Stulz D, Staab JE, Skrinar GS, Lewis SF, Sawka MN
  Intermittent altitude exposures reduce acute mountain sickness at 4300 m. Clin Sci (Lond). 2004 Mar;106(3):321-8.
•   Droma Y, Hanaoka M, Ota M, Katsuyama Y, Koizumi T, Fujimoto K, Kobayashi T, Kubo K
  Positive association of the endothelial nitric oxide synthase gene polymorphisms with high-altitude pulmonary edema. Circulation. 2002 Aug 13;106(7):826-30.
•   Follmann M, Griebenow N, Hahn MG, Hartung I, Mais FJ, Mittendorf J, Schäfer M, Schirok H, Stasch JP, Stoll F, Straub A
  The chemistry and biology of soluble guanylate cyclase stimulators and activators. Angew Chem Int Ed Engl. 2013 Sep 2;52(36):9442-62. doi: 10.1002/anie.201302588. Epub 2013 Aug 20. Review.
•   Forster PJ
  Effect of different ascent profiles on performance at 4,200 m elevation. Aviat Space Environ Med. 1985 Aug;56(8):758-64.
•   Frey R, Mück W, Unger S, Artmeier-Brandt U, Weimann G, Wensing G
  Single-dose pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase stimulator BAY 63-2521: an ascending-dose study in healthy male volunteers. J Clin Pharmacol. 2008 Aug;48(8):926-34. doi: 10.1177/0091270008319793. Epub 2008 Jun 2.
•   Frezza EE, Mezghebe H
  Indications and complications of arterial catheter use in surgical or medical intensive care units: analysis of 4932 patients. Am Surg. 1998 Feb;64(2):127-31.
•   Gale GE, Torre-Bueno JR, Moon RE, Saltzman HA, Wagner PD
  Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude. J Appl Physiol (1985). 1985 Mar;58(3):978-88.
•   Ghofrani HA, D'Armini AM, Grimminger F, Hoeper MM, Jansa P, Kim NH, Mayer E, Simonneau G, Wilkins MR, Fritsch A, Neuser D, Weimann G, Wang C; CHEST-1 Study Group
  Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. N Engl J Med. 2013 Jul 25;369(4):319-29. doi: 10.1056/NEJMoa1209657.
•   Ghofrani HA, Galiè N, Grimminger F, Grünig E, Humbert M, Jing ZC, Keogh AM, Langleben D, Kilama MO, Fritsch A, Neuser D, Rubin LJ; PATENT-1 Study Group
  Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med. 2013 Jul 25;369(4):330-40. doi: 10.1056/NEJMoa1209655.
•   Ghofrani HA, Reichenberger F, Kohstall MG, Mrosek EH, Seeger T, Olschewski H, Seeger W, Grimminger F
  Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med. 2004 Aug 3;141(3):169-77.
•   Hornbein TF, Townes BD, Schoene RB, Sutton JR, Houston CS
  The cost to the central nervous system of climbing to extremely high altitude. N Engl J Med. 1989 Dec 21;321(25):1714-9.
•   Hughson RL, Yamamoto Y, McCullough RE, Sutton JR, Reeves JT
  Sympathetic and parasympathetic indicators of heart rate control at altitude studied by spectral analysis. J Appl Physiol (1985). 1994 Dec;77(6):2537-42.
•   Jensen LA, Onyskiw JE, Prasad NG
  Meta-analysis of arterial oxygen saturation monitoring by pulse oximetry in adults. Heart Lung. 1998 Nov-Dec;27(6):387-408.
•   Lundberg JO, Weitzberg E, Gladwin MT
  The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008 Feb;7(2):156-67. doi: 10.1038/nrd2466. Review.
•   Luo Y, Chen Y, Zhang Y, Zhou Q, Gao Y
  Association of endothelial nitric oxide synthase (eNOS) G894T polymorphism with high altitude pulmonary edema susceptibility: a meta-analysis. Wilderness Environ Med. 2012 Sep;23(3):270-4. doi: 10.1016/j.wem.2012.03.007. Epub 2012 Jul 13. Review.
•   McMahon TJ, Ahearn GS, Moya MP, Gow AJ, Huang YC, Luchsinger BP, Nudelman R, Yan Y, Krichman AD, Bashore TM, Califf RM, Singel DJ, Piantadosi CA, Tapson VF, Stamler JS
  A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14801-6. Epub 2005 Oct 3.
•   McMahon TJ, Moon RE, Luschinger BP, Carraway MS, Stone AE, Stolp BW, Gow AJ, Pawloski JR, Watke P, Singel DJ, Piantadosi CA, Stamler JS
  Nitric oxide in the human respiratory cycle. Nat Med. 2002 Jul;8(7):711-7. Epub 2002 Jun 3.
•   Mummery HJ, Stolp BW, deL Dear G, Doar PO, Natoli MJ, Boso AE, Archibald JD, Hobbs GW, El-Moalem HE, Moon RE
  Effects of age and exercise on physiological dead space during simulated dives at 2.8 ATA. J Appl Physiol (1985). 2003 Feb;94(2):507-17. Epub 2002 Oct 11.
•   Richalet JP, Gratadour P, Robach P, Pham I, Déchaux M, Joncquiert-Latarjet A, Mollard P, Brugniaux J, Cornolo J
  Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am J Respir Crit Care Med. 2005 Feb 1;171(3):275-81. Epub 2004 Oct 29.
•   Rock PB, Johnson TS, Cymerman A, Burse RL, Falk LJ, Fulco CS
  Effect of dexamethasone on symptoms of acute mountain sickness at Pikes Peak, Colorado (4,300 m). Aviat Space Environ Med. 1987 Jul;58(7):668-72.
•   Rubin LJ, Naeije R
  Sildenafil for enhanced performance at high altitude? Ann Intern Med. 2004 Aug 3;141(3):233-5.
•   Sampson JB, Cymerman A, Burse RL, Maher JT, Rock PB
  Procedures for the measurement of acute mountain sickness. Aviat Space Environ Med. 1983 Dec;54(12 Pt 1):1063-73.
•   Scherrer U, Vollenweider L, Delabays A, Savcic M, Eichenberger U, Kleger GR, Fikrle A, Ballmer PE, Nicod P, Bärtsch P
  Inhaled nitric oxide for high-altitude pulmonary edema. N Engl J Med. 1996 Mar 7;334(10):624-9.
•   Slogoff S, Keats AS, Arlund C
  On the safety of radial artery cannulation. Anesthesiology. 1983 Jul;59(1):42-7.
•   Torre-Bueno JR, Wagner PD, Saltzman HA, Gale GE, Moon RE
  Diffusion limitation in normal humans during exercise at sea level and simulated altitude. J Appl Physiol (1985). 1985 Mar;58(3):989-95.
•   Valentine RJ, Modrall JG, Clagett GP
  Hand ischemia after radial artery cannulation. J Am Coll Surg. 2005 Jul;201(1):18-22.
•   Wagner PD, Gale GE, Moon RE, Torre-Bueno JR, Stolp BW, Saltzman HA
  Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J Appl Physiol (1985). 1986 Jul;61(1):260-70.
•   West JB
  Improving oxygenation at high altitude: acclimatization and O2 enrichment. High Alt Med Biol. 2003 Fall;4(3):389-98.

The Effect of Riociguat on Gas Exchange, Exercise Performance, and Pulmonary Artery Pressure During Acute Altitude Exposure

Details for clinical trial NCT02024386