Hypertension — Blood Pressure Control in Juveniles - Longitudinal Study
Citation(s)
Ambrosius WT, Compton JA, Bowsher RR, Pratt JH Relation of race, age, and sex hormone differences to serum leptin concentrations in children and adolescents. Horm Res. 1998;49(5):240-6.
Ambrosius WT, Newman SA, Pratt JH Rates of change in measures of body size vary by ethnicity and gender. Ethn Dis. 2001 Spring-Summer;11(2):303-10.
Bloem LJ, Guo C, Pratt JH Identification of a splice variant of the rat and human mineralocorticoid receptor genes. J Steroid Biochem Mol Biol. 1995 Nov;55(2):159-62.
Bloem LJ, Manatunga AK, Pratt JH Racial difference in the relationship of an angiotensin I-converting enzyme gene polymorphism to serum angiotensin I-converting enzyme activity. Hypertension. 1996 Jan;27(1):62-6.
Bloem LJ, Manatunga AK, Tewksbury DA, Pratt JH The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children. J Clin Invest. 1995 Mar;95(3):948-53.
Chun TY, Pratt JH Non-genomic effects of aldosterone: new actions and questions. Trends Endocrinol Metab. 2004 Oct;15(8):353-4.
Jakubowski H, Ambrosius WT, Pratt JH Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis. FEBS Lett. 2001 Feb 23;491(1-2):35-9.
Manatunga AK, Jones JJ, Pratt JH Longitudinal assessment of blood pressures in black and white children. Hypertension. 1993 Jul;22(1):84-9.
Pratt JH, Eckert GJ, Newman S, Ambrosius WT Blood pressure responses to small doses of amiloride and spironolactone in normotensive subjects. Hypertension. 2001 Nov;38(5):1124-9.
Pratt JH, Manatunga AK, Bloem LJ, Li W Racial differences in aldosterone excretion: a longitudinal study in children. J Clin Endocrinol Metab. 1993 Dec;77(6):1512-5.
Pratt JH, Manatunga AK, Li W Familial influences on the adrenal androgen excretion rate during the adrenarche. Metabolism. 1994 Feb;43(2):186-9.
Pratt JH, Manatunga AK, Peacock M A comparison of the urinary excretion of bone resorptive products in white and black children. J Lab Clin Med. 1996 Jan;127(1):67-70.
Saha C, Eckert GJ, Pratt JH, Shankar RR Onset of overweight during childhood and adolescence in relation to race and sex. J Clin Endocrinol Metab. 2005 May;90(5):2648-52. Epub 2005 Feb 22. Erratum in: J Clin Endocrinol Metab. 2005 Jul;90(7):4286.
Shackleton CH, Kletke C, Wudy S, Pratt JH Dehydroepiandrosterone sulfate quantification in serum using high-performance liquid chromatography/mass spectrometry and a deuterated internal standard: a technique suitable for routine use or as a reference method. Steroids. 1990 Oct;55(10):472-8.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
