Hyperbilirubinemia, Neonatal — The Effect of Massage on the Bilirubin Level in Term Infants Receiving Phototherapy
Citation(s)
Ahmadipour S, Mardani M, Mohsenzadeh A, Baharvand P, Nazeri MG The Lowering of Bilirubin Levels in Full-Term Newborns by the Effect of Combined Massage Therapy and Phototherapy Practice. Am J Perinatol. 2019 Apr 18. doi: 10.1055/s-0039-1685493. [Epub ahe
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Garg BD, Kabra NS, Balasubramanian H Role of massage therapy on reduction of neonatal hyperbilirubinemia in term and preterm neonates: a review of clinical trials. J Matern Fetal Neonatal Med. 2019 Jan;32(2):301-309. doi: 10.1080/14767058.2017.1376316. E
Gözen D, Yilmaz ÖE, Dur S, Çaglayan S, Tastekin A Transcutaneous bilirubin levels of newborn infants performed abdominal massage: A randomized controlled trial. J Spec Pediatr Nurs. 2019 Apr;24(2):e12237. doi: 10.1111/jspn.12237. Epub 2019 Feb 28.
Korkmaz G, Esenay FI Effects of Massage Therapy on Indirect Hyperbilirubinemia in Newborns Who Receive Phototherapy. J Obstet Gynecol Neonatal Nurs. 2020 Jan;49(1):91-100. doi: 10.1016/j.jogn.2019.11.004. Epub 2019 Dec 6.
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Lin CH, Yang HC, Cheng CS, Yen CE Effects of infant massage on jaundiced neonates undergoing phototherapy. Ital J Pediatr. 2015 Nov 25;41:94. doi: 10.1186/s13052-015-0202-y.
Olusanya BO, Kaplan M, Hansen TWR Neonatal hyperbilirubinaemia: a global perspective. Lancet Child Adolesc Health. 2018 Aug;2(8):610-620. doi: 10.1016/S2352-4642(18)30139-1. Epub 2018 Jun 28. Review.
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The Effect of Massage on the Bilirubin Level in Term Infants Receiving Phototherapy
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
