HIV — Effects of Aerobic Exercise on CD4 Count,Viral Load,Selected Psycho-social Trait
Citation(s)
Gomes RD, Borges JP, Lima DB, Farinatti PT Effects of physical exercise in the perception of life satisfaction and immunological function in HIV-infected patients: Non-randomized clinical trial. Rev Bras Fisioter. 2010 Sep-Oct;14(5):390-5. English, Portuguese.
Nixon S, O'Brien K, Glazier RH, Tynan AM Aerobic exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst Rev. 2002;(2):CD001796. Review. Update in: Cochrane Database Syst Rev. 2005;(2):CD001796.
Nixon S, O'Brien K, Glazier RH, Tynan AM Aerobic exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD001796. Review. Update in: Cochrane Database Syst Rev. 2010;(8):CD001796.
O'Brien K, Nixon S, Tynan AM, Glazier R Aerobic exercise interventions for adults living with HIV/AIDS. Cochrane Database Syst Rev. 2010 Aug 4;(8):CD001796. doi: 10.1002/14651858.CD001796.pub3. Review.
Stringer WW HIV and aerobic exercise. Current recommendations. Sports Med. 1999 Dec;28(6):389-95.
Terry L, Sprinz E, Ribeiro JP Moderate and high intensity exercise training in HIV-1 seropositive individuals: a randomized trial. Int J Sports Med. 1999 Feb;20(2):142-6.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
