HIV — Maternal HIV Disclosure to School Children: RCT of Family-based Intervention
Citation(s)
Mkwanazi N , Rochat T.J, Coetzee B., Bland R. (2013) Mothers' and health workers' perceptions of participation in a child-friendly health initiative in rural South Africa. Health, 5(12), 2137-2145. doi: 10.4236/health.2013.512291 NO PMID
Mkwanazi NB, Rochat TJ, Bland RM Living with HIV, disclosure patterns and partnerships a decade after the introduction of HIV programmes in rural South Africa. AIDS Care. 2015;27 Suppl 1:65-72. doi: 10.1080/09540121.2015.1028881.
Mkwanazi, N B., Rochat, T. J., Imrie, J., & Bland, R. M. (2012). Disclosure of maternal HIV status to children: considerations for research and practice in sub-Saharan Africa. Future Virology, 7(12), 1159-1182. NO PMID
Rochat T, Mitchell J, Stein A, Mkwanazi N, Bland R The Amagugu Intervention: A conceptual framework for increasing HIV disclosure and parent-led communication about health and HIV prevention among HIV-infected parents with HIV-uninfected primary school-aged children. Frontiers in Public Health. 2016; 4(183).
Rochat TJ, Arteche AX, Stein A, Mitchell J, Bland RM Maternal and child psychological outcomes of HIV disclosure to young children in rural South Africa: the Amagugu intervention. AIDS. 2015 Jun;29 Suppl 1:S67-79. doi: 10.1097/QAD.0000000000000668.
Rochat TJ, Arteche AX, Stein A, Mkwanazi N, Bland RM Maternal HIV disclosure to young HIV-uninfected children: an evaluation of a family-centred intervention in South Africa. AIDS. 2014 Jul;28 Suppl 3:S331-41. doi: 10.1097/QAD.0000000000000333. Erratum in: AIDS. 2014 Nov 13;28(17):2641.
Rochat TJ, Bland R, Coovadia H, Stein A, Newell ML Towards a family-centered approach to HIV treatment and care for HIV-exposed children, their mothers and their families in poorly resourced settings. Future Virol. 2011 Jun;6(6):687-696.
Rochat TJ, Mkwanazi N, Bland R Maternal HIV disclosure to HIV-uninfected children in rural South Africa: a pilot study of a family-based intervention. BMC Public Health. 2013 Feb 18;13:147. doi: 10.1186/1471-2458-13-147.
Maternal HIV Disclosure to School Children: RCT of Family-based Intervention (Amagugu)
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
