Balamurugan S, Agrawal A, Kato Y, Sano H Intra operative indocyanine green video-angiography in cerebrovascular surgery: An overview with review of literature. Asian J Neurosurg. 2011 Jul;6(2):88-93. doi: 10.4103/1793-5482.92168.
Cochran ST, Bomyea K, Sayre JW Trends in adverse events after IV administration of contrast media. AJR Am J Roentgenol. 2001 Jun;176(6):1385-8. doi: 10.2214/ajr.176.6.1761385.
Elsaied A, Aly K, Thabet W, Magdy A Two-stage repair of low anorectal malformations in girls: is it truly a setback?. Annals of Pediatric Surgery. 2013;9(2):69-73.
Emran M, Wayne C, Koehler SM, Almond PS, Patel H Intraoperative ICG-NIR Fluorescence Angiography Visualization of Intestinal Perfusion in Primary Pull-Through for Hirschsprung Disease. International Journal of Medical and Health Sciences. 2020 Nov 1;14(12):408-11
Engum SA, Grosfeld JL Long-term results of treatment of Hirschsprung's disease. Semin Pediatr Surg. 2004 Nov;13(4):273-85. doi: 10.1053/j.sempedsurg.2004.10.015.
Kudszus S, Roesel C, Schachtrupp A, Hoer JJ Intraoperative laser fluorescence angiography in colorectal surgery: a noninvasive analysis to reduce the rate of anastomotic leakage. Langenbecks Arch Surg. 2010 Nov;395(8):1025-30. doi: 10.1007/s00423-010-0699-x. Epub 2010 Aug 12.
Lu C, Hou G, Liu C, Geng Q, Xu X, Zhang J, Chen H, Tang W Single-stage transanal endorectal pull-through procedure for correction of Hirschsprung disease in neonates and nonneonates: A multicenter study. J Pediatr Surg. 2017 Jul;52(7):1102-1107. doi: 10.1016/j.jpedsurg.2017.01.061. Epub 2017 Feb 2.
Mundt E, Bates MD Genetics of Hirschsprung disease and anorectal malformations. Semin Pediatr Surg. 2010 May;19(2):107-17. doi: 10.1053/j.sempedsurg.2009.11.015.
Tofft L, Salo M, Arnbjornsson E, Stenstrom P Wound Dehiscence after Posterior Sagittal Anorectoplasty in Children with Anorectal Malformations. Biomed Res Int. 2018 Nov 11;2018:2930783. doi: 10.1155/2018/2930783. eCollection 2018.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
