Hemispatial Neglect — Virtual Reality Attention Training in Stroke Patients
Citation(s)
Andersen SW, Millen BA On the practical application of mixed effects models for repeated measures to clinical trial data. Pharm Stat. 2013 Jan-Feb;12(1):7-16. doi: 10.1002/pst.1548. Epub 2012 Dec 13.
Dent K, Humphreys GW Neuropsychological evidence for a competitive bias against contracting stimuli. Neurocase. 2011;17(2):112-21. doi: 10.1080/13554794.2010.498381. Epub 2010 Sep 1.
Green, P , MacLeod, CJ. SIMR: an R package for power analysis of generalized linear mixed models by simulation. Methods in Ecology and Evolution, 7(4): 493-498, 2016.
Kass, RE , Raftery, AE. Bayes Factors. Journal of the Americal Statistical Association, 90(430): 773-795, 1995.
Nijboer TC, Kollen BJ, Kwakkel G Time course of visuospatial neglect early after stroke: a longitudinal cohort study. Cortex. 2013 Sep;49(8):2021-7. doi: 10.1016/j.cortex.2012.11.006. Epub 2012 Dec 19.
Van den Noortgate, W , Onghena, P. Combining Single-Case Experimental Data Using Hierarchical Linear Models. School Psychology Quarterly Fall 2003, 18(3): 325-346, 2003.
Virtual Reality Attention Training in Stroke Patients
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
