NCT05164302 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Guan L, Li G, Yang Y, Deng X, Cai P
Infrared thermography and meridian-effect evidence and explanation in Bell's palsy patients treated by moxibustion at the Hegu (LI4) acupoint: Overall regulation or a specific target? Neural Regen Res. 2012 Mar 25;7(9):680-5. doi: 10.3969/j.issn.1673-5374.2012.09.007.
Hou PW, Hsu HC, Lin YW, Tang NY, Cheng CY, Hsieh CL
The History, Mechanism, and Clinical Application of Auricular Therapy in Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2015;2015:495684. doi: 10.1155/2015/495684. Epub 2015 Dec 28.
Tsuruoka N, Katayama S, Seki T, Matsunaga T, Iijima R, Haga Y
Focused Ultrasound PC-6 Stimulation Effects on Blood Flow Volume, Skin Temperature, and Coldness of the Finger and Toe. Complement Med Res. 2019;26(6):404-409. doi: 10.1159/000501149. Epub 2019 Jul 5.
Wang D, Ji B, Yan M, Bai H, Sun X, Dai J, Lu Y, Liu Y, You M, Wu J, Ge Y, Su H, Cheng K, Zhao G
Effect of electroacpuncture of Neiguan (PC 6) and Tianquan (PC 2) on skin temperature, blood perfusion, and adrenoceptor response in rats with acute myocardial ischemia. J Tradit Chin Med. 2017 Dec;37(6):794-803.

Survey on Skin Surface's Temperature Change When Auricular Acupuncture at Jaw Point (LO1) and Tooth Point (LO3) on Heatlhy Volunteer: a Pilot Study

Clinical trial NCT05164302 - References