Healthy — Non-invasive Measurement of Microvascular Blood Flow During Mild External Compression of the Leg
Citation(s)
Abu-Own A, Cheatle T, Scurr JH, Coleridge Smith PD Effects of intermittent pneumatic compression of the foot on the microcirculatory function in arterial disease. Eur J Vasc Surg. 1993 Sep;7(5):488-92.
Agu O, Baker D, Seifalian AM Effect of graduated compression stockings on limb oxygenation and venous function during exercise in patients with venous insufficiency. Vascular. 2004 Jan;12(1):69-76.
Jünger M, Steins A, Hahn M, Häfner HM Microcirculatory dysfunction in chronic venous insufficiency (CVI). Microcirculation. 2000;7(6 Pt 2):S3-12. Review.
Mateus J, Hargens AR Bone hemodynamic responses to changes in external pressure. Bone. 2013 Feb;52(2):604-10. doi: 10.1016/j.bone.2012.11.010. Epub 2012 Nov 17.
Mateus J, Hargens AR Photoplethysmography for non-invasive in vivo measurement of bone hemodynamics. Physiol Meas. 2012 Jun;33(6):1027-42. doi: 10.1088/0967-3334/33/6/1027. Epub 2012 May 4.
Morris RJ, Woodcock JP Effects of supine intermittent compression on arterial inflow to the lower limb. Arch Surg. 2002 Nov;137(11):1269-73.
Morris RJ, Woodcock JP Evidence-based compression: prevention of stasis and deep vein thrombosis. Ann Surg. 2004 Feb;239(2):162-71.
Morris RJ, Woodcock JP Intermittent venous compression, and the duration of hyperaemia in the common femoral artery. Clin Physiol Funct Imaging. 2004 Jul;24(4):237-42.
Nielsen HV Effects of externally applied compression on blood flow in subcutaneous and muscle tissue in the human supine leg. Clin Physiol. 1982 Dec;2(6):447-57.
Nielsen HV External pressure--blood flow relations during limb compression in man. Acta Physiol Scand. 1983 Nov;119(3):253-60.
Porter JM, Moneta GL Reporting standards in venous disease: an update. International Consensus Committee on Chronic Venous Disease. J Vasc Surg. 1995 Apr;21(4):635-45.
Sandberg M, Zhang Q, Styf J, Gerdle B, Lindberg LG Non-invasive monitoring of muscle blood perfusion by photoplethysmography: evaluation of a new application. Acta Physiol Scand. 2005 Apr;183(4):335-43.
Zhang Q, Lindberg LG, Kadefors R, Styf J A non-invasive measure of changes in blood flow in the human anterior tibial muscle. Eur J Appl Physiol. 2001 May;84(5):448-52.
Zhang Q, Styf J, Lindberg LG Effects of limb elevation and increased intramuscular pressure on human tibialis anterior muscle blood flow. Eur J Appl Physiol. 2001 Oct;85(6):567-71.
Non-invasive Measurement of Microvascular Blood Flow During Mild External Compression of the Leg
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