Clinical trial NCT05529953 - References

Healthy Subjects — Bioavailability of Oleanolic Acid Formulated as Functional Olive Oil

Citation(s)

•   Castellano JM, Guinda A, Delgado T, Rada M, Cayuela JA
  Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes. 2013 Jun;62(6):1791-9. doi: 10.2337/db12-1215. Review.
•   Castellano JM, Ramos-Romero S, Perona JS
  Oleanolic Acid: Extraction, Characterization and Biological Activity. Nutrients. 2022 Jan 31;14(3). pii: 623. doi: 10.3390/nu14030623. Review.
•   Fernández-Aparicio Á, Correa-Rodríguez M, Castellano JM, Schmidt-RioValle J, Perona JS, González-Jiménez E
  Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review. Antioxidants (Basel). 2022 Aug 3;11(8). pii: 1517. doi: 10.3390/antiox11081517. Review.
•   Guinda A, Rada M, Delgado T, Gutiérrez-Adánez P, Castellano JM
  Pentacyclic triterpenoids from olive fruit and leaf. J Agric Food Chem. 2010 Sep 8;58(17):9685-91. doi: 10.1021/jf102039t.
•   Jiménez-Sánchez A, Martínez-Ortega AJ, Remón-Ruiz PJ, Piñar-Gutiérrez A, Pereira-Cunill JL, García-Luna PP
  Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update. Nutrients. 2022 Mar 31;14(7). pii: 1440. doi: 10.3390/nu14071440. Review.
•   Karpe F, Tornvall P, Olivecrona T, Steiner G, Carlson LA, Hamsten A
  Composition of human low density lipoprotein: effects of postprandial triglyceride-rich lipoproteins, lipoprotein lipase, hepatic lipase and cholesteryl ester transfer protein. Atherosclerosis. 1993 Jan 4;98(1):33-49.
•   Rada M, Castellano JM, Perona JS, Guinda Á
  GC-FID determination and pharmacokinetic studies of oleanolic acid in human serum. Biomed Chromatogr. 2015 Nov;29(11):1687-92. doi: 10.1002/bmc.3480. Epub 2015 May 5.
•   Santos-Lozano JM, Rada M, Lapetra J, Guinda Á, Jiménez-Rodríguez MC, Cayuela JA, Ángel-Lugo A, Vilches-Arenas Á, Gómez-Martín AM, Ortega-Calvo M, Castellano JM
  Prevention of type 2 diabetes in prediabetic patients by using functional olive oil enriched in oleanolic acid: The PREDIABOLE study, a randomized controlled trial. Diabetes Obes Metab. 2019 Nov;21(11):2526-2534. doi: 10.1111/dom.13838. Epub 2019 Aug 28.

Bioavailability Assays of Oleanolic Acid, Formulated as Functional Olive Oil, in Healthy Subjects. Pharmacokinetic Analysis and Study of Its Integration in Postprandial Human Triglyceride-Rich Lipoproteins

Details for clinical trial NCT05529953