Citation(s)
- Banov L Jr, Knoepp LF Jr, Erdman LH, Alia RT
Management of hemorrhoidal disease. J S C Med Assoc. 1985 Jul;81(7):398-401. No abstract available.
- Bhatt A
Protocol deviation and violation. Perspect Clin Res. 2012 Jul;3(3):117. doi: 10.4103/2229-3485.100663. No abstract available.
- Colak T, Akca T, Dirlik M, Kanik A, Dag A, Aydin S
Micronized flavonoids in pain control after hemorrhoidectomy: a prospective randomized controlled study. Surg Today. 2003;33(11):828-32. doi: 10.1007/s00595-003-2604-5.
- Corsale I, Carrieri P, Martellucci J, Piccolomini A, Verre L, Rigutini M, Panicucci S
Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study. Int J Colorectal Dis. 2018 Nov;33(11):1595-1600. doi: 10.1007/s00384-018-3102-y. Epub 2018 Jun 22.
- Cospite M
Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids. Angiology. 1994 Jun;45(6 Pt 2):566-73.
- Durga M
International Journal of Pharma and Bio Sciences MULTIFARIOUS ACTIONS OF DIETARY FLAVONOIDS IMPLICATIONS IN CANCER AND CATARACT ABSTRACT [Internet]. kipdf.com. [cited 2022 Jun 24]. Available from: https://kipdf.com/international-journal-of-pharma-and-bio-sciences-multifarious-actions-of-dietary_5ada41157f8b9a2e7e8b45c7.html
- Everhart JE, Ruhl CE
Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology. 2009 Feb;136(2):376-86. doi: 10.1053/j.gastro.2008.12.015. Epub 2009 Jan 3. No abstract available.
- Faul F, Erdfelder E, Lang AG, Buchner A
G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007 May;39(2):175-91. doi: 10.3758/bf03193146.
- Frank L, Kleinman L, Farup C, Taylor L, Miner P Jr
Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroenterol. 1999 Sep;34(9):870-7. doi: 10.1080/003655299750025327.
- Ganz RA
The evaluation and treatment of hemorrhoids: a guide for the gastroenterologist. Clin Gastroenterol Hepatol. 2013 Jun;11(6):593-603. doi: 10.1016/j.cgh.2012.12.020. Epub 2013 Jan 16. No abstract available.
- Ghooi RB, Bhosale N, Wadhwani R, Divate P, Divate U
Assessment and classification of protocol deviations. Perspect Clin Res. 2016 Jul-Sep;7(3):132-6. doi: 10.4103/2229-3485.184817.
- Giannini I, Amato A, Basso L, Tricomi N, Marranci M, Pecorella G, Tafuri S, Pennisi D, Altomare DF
Erratum to: Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloproctol. 2015 Oct;19(10):665-6. doi: 10.1007/s10151-015-1357-7. No abstract available.
- Giannini I, Amato A, Basso L, Tricomi N, Marranci M, Pecorella G, Tafuri S, Pennisi D, Altomare DF
Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloproctol. 2015 Jun;19(6):339-45. doi: 10.1007/s10151-015-1302-9. Epub 2015 Apr 19. Erratum In: Tech Coloproctol. 2015 Oct;19(10):665-6.
- Godeberge P, Sheikh P, Lohsiriwat V, Jalife A, Shelygin Y
Micronized purified flavonoid fraction in the treatment of hemorrhoidal disease. J Comp Eff Res. 2021 Jul;10(10):801-813. doi: 10.2217/cer-2021-0038. Epub 2021 Apr 30.
- Heaton ND, Davenport M, Howard ER
Symptomatic hemorrhoids and anorectal varices in children with portal hypertension. J Pediatr Surg. 1992 Jul;27(7):833-5. doi: 10.1016/0022-3468(92)90377-j.
- Hjortswang H, Jarnerot G, Curman B, Sandberg-Gertzen H, Tysk C, Blomberg B, Almer S, Strom M
The Short Health Scale: a valid measure of subjective health in ulcerative colitis. Scand J Gastroenterol. 2006 Oct;41(10):1196-203. doi: 10.1080/00365520600610618.
- Jiang ZM, Cao JD
The impact of micronized purified flavonoid fraction on the treatment of acute haemorrhoidal episodes. Curr Med Res Opin. 2006 Jun;22(6):1141-7. doi: 10.1185/030079906X104803.
- Johanson JF, Sonnenberg A
The prevalence of hemorrhoids and chronic constipation. An epidemiologic study. Gastroenterology. 1990 Feb;98(2):380-6. doi: 10.1016/0016-5085(90)90828-o.
- La Torre F, Nicolai AP, Otti M
[Hemorrhoids and conservative treatment. Review of the literature on the use of diosmin and micronized hesperidin]. Minerva Chir. 1999 Dec;54(12):909-16. No abstract available. Italian.
- La Torre F, Nicolai AP
Clinical use of micronized purified flavonoid fraction for treatment of symptoms after hemorrhoidectomy: results of a randomized, controlled, clinical trial. Dis Colon Rectum. 2004 May;47(5):704-10. doi: 10.1007/s10350-003-0119-1. Epub 2004 Mar 25.
- Lebeau J, Furman C, Bernier JL, Duriez P, Teissier E, Cotelle N
Antioxidant properties of di-tert-butylhydroxylated flavonoids. Free Radic Biol Med. 2000 Nov 1;29(9):900-12. doi: 10.1016/s0891-5849(00)00390-7.
- Lichota A, Gwozdzinski L, Gwozdzinski K
Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. Eur J Med Chem. 2019 Aug 15;176:68-91. doi: 10.1016/j.ejmech.2019.04.075. Epub 2019 May 6.
- Lohsiriwat V
Hemorrhoids: from basic pathophysiology to clinical management. World J Gastroenterol. 2012 May 7;18(17):2009-17. doi: 10.3748/wjg.v18.i17.2009.
- Lyseng-Williamson KA, Perry CM
Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids. Drugs. 2003;63(1):71-100. doi: 10.2165/00003495-200363010-00005.
- Monograph
Diosmin. Altern Med Rev. 2004 Sep;9(3):308-11. No abstract available.
- Panche AN, Diwan AD, Chandra SR
Flavonoids: an overview. J Nutr Sci. 2016 Dec 29;5:e47. doi: 10.1017/jns.2016.41. eCollection 2016.
- Perera N, Liolitsa D, Iype S, Croxford A, Yassin M, Lang P, Ukaegbu O, van Issum C
Phlebotonics for haemorrhoids. Cochrane Database Syst Rev. 2012 Aug 15;(8):CD004322. doi: 10.1002/14651858.CD004322.pub3.
- Rabe E, Guex JJ, Morrison N, Ramelet AA, Schuller-Petrovic S, Scuderi A, Staelens I, Pannier F
Treatment of chronic venous disease with flavonoids: recommendations for treatment and further studies. Phlebology. 2013 Sep;28(6):308-19. doi: 10.1177/0268355512471929. Epub 2013 May 6.
- Rorvik HD, Styr K, Ilum L, McKinstry GL, Dragesund T, Campos AH, Brandstrup B, Olaison G
Hemorrhoidal Disease Symptom Score and Short Health ScaleHD: New Tools to Evaluate Symptoms and Health-Related Quality of Life in Hemorrhoidal Disease. Dis Colon Rectum. 2019 Mar;62(3):333-342. doi: 10.1097/DCR.0000000000001234.
- Rubbini M, Ascanelli S
Classification and guidelines of hemorrhoidal disease: Present and future. World J Gastrointest Surg. 2019 Mar 27;11(3):117-121. doi: 10.4240/wjgs.v11.i3.117.
- Russo R, Chandradhara D, De Tommasi N
Comparative Bioavailability of Two Diosmin Formulations after Oral Administration to Healthy Volunteers. Molecules. 2018 Aug 29;23(9):2174. doi: 10.3390/molecules23092174.
- Russo R, Mancinelli A, Ciccone M, Terruzzi F, Pisano C, Severino L
Pharmacokinetic Profile of microSMIN Plus, a new Micronized Diosmin Formulation, after Oral Administration in Rats. Nat Prod Commun. 2015 Sep;10(9):1569-72.
- Sanchez C, Chinn BT
Hemorrhoids. Clin Colon Rectal Surg. 2011 Mar;24(1):5-13. doi: 10.1055/s-0031-1272818.
- Serra R, Ielapi N, Bitonti A, Candido S, Fregola S, Gallo A, Loria A, Muraca L, Raimondo L, Velcean L, Guadagna S, Gallelli L
Efficacy of a Low-Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Mar 19;13(3):999. doi: 10.3390/nu13030999.
- Sheikh P, Lohsiriwat V, Shelygin Y
Micronized Purified Flavonoid Fraction in Hemorrhoid Disease: A Systematic Review and Meta-Analysis. Adv Ther. 2020 Jun;37(6):2792-2812. doi: 10.1007/s12325-020-01353-7. Epub 2020 May 12.
- Slappendel R, Simpson K, Dubois D, Keininger DL
Validation of the PAC-SYM questionnaire for opioid-induced constipation in patients with chronic low back pain. Eur J Pain. 2006 Apr;10(3):209-17. doi: 10.1016/j.ejpain.2005.03.008.
- Snow G
blockrand: Randomization for Block Random Clinical Trials [Internet]. 2020 [cited 2022 Jun 9]. Available from: https://CRAN.R-project.org/package=blockrand
- Stjernman H, Granno C, Jarnerot G, Ockander L, Tysk C, Blomberg B, Strom M, Hjortswang H
Short health scale: a valid, reliable, and responsive instrument for subjective health assessment in Crohn's disease. Inflamm Bowel Dis. 2008 Jan;14(1):47-52. doi: 10.1002/ibd.20255.
- Sun Z, Migaly J
Review of Hemorrhoid Disease: Presentation and Management. Clin Colon Rectal Surg. 2016 Mar;29(1):22-9. doi: 10.1055/s-0035-1568144.
- Szyca R, Leksowski K
Assessment of patients' quality of life after haemorrhoidectomy using the LigaSure device. Wideochir Inne Tech Maloinwazyjne. 2015 Apr;10(1):68-72. doi: 10.5114/wiitm.2015.49672. Epub 2015 Mar 10.
- Thomson JPS, Goligher JC
Surgery of the anus, rectum and colon. J. C. Goligher. Fourth Edition. 264 × 198 mm. Pp. 968 + vii, with 654 illustrations. 1980. London: Baillière Tindall. £35·00. BJS Br J Surg. 1980;67(7):532-532
- Tjandra JJ, Tan JJ, Lim JF, Murray-Green C, Kennedy ML, Lubowski DZ
Rectogesic (glyceryl trinitrate 0.2%) ointment relieves symptoms of haemorrhoids associated with high resting anal canal pressures. Colorectal Dis. 2007 Jun;9(5):457-63. doi: 10.1111/j.1463-1318.2006.01134.x.
- Uschner D, Schindler D, Hilgers RD, Heussen N
randomizeR : An R Package for the Assessment and Implementation of Randomization in Clinical Trials. J Stat Softw [Internet]. 2018 [cited 2022 Jun 9];85(8). Available from: http://www.jstatsoft.org/v85/i08/
Randomised, Double-blind, Placebo-controlled, Parallel-group, Multicentre, Interventional Clinical Trial to Assess the Efficacy and Safety of the Food Supplement Microsmin® Plus in the Symptomatic Treatment of Haemorrhoids
Details for clinical trial NCT05750563
