Gynecologic Surgical Procedures — Barbed vs Standard Suture for Laparoscopic Vaginal Cuff Closure
Citation(s)
ACOG Committee Opinion No 444: choosing the route of hysterectomy for benign disease. Obstet Gynecol. 2009 Nov;114(5):1156-8. doi: 10.1097/AOG.0b013e3181c33c72.
Chan WS, Kong KK, Nikam YA, Merkur H Vaginal vault dehiscence after laparoscopic hysterectomy over a nine-year period at Sydney West Advanced Pelvic Surgery Unit - our experiences and current understanding of vaginal vault dehiscence. Aust N Z J Obstet G
Cohen SL, Einarsson JI Total and supracervical hysterectomy. Obstet Gynecol Clin North Am. 2011 Dec;38(4):651-61. doi: 10.1016/j.ogc.2011.09.002. Review.
Hwang JH, Lee JK, Lee NW, Lee KW Vaginal cuff closure: a comparison between the vaginal route and laparoscopic suture in patients undergoing total laparoscopic hysterectomy. Gynecol Obstet Invest. 2011;71(3):163-9. doi: 10.1159/000316052.
Jeung IC, Baek JM, Park EK, Lee HN, Kim CJ, Park TC, Lee YS A prospective comparison of vaginal stump suturing techniques during total laparoscopic hysterectomy. Arch Gynecol Obstet. 2010 Dec;282(6):631-8. doi: 10.1007/s00404-009-1300-0.
Villa MT, White LE, Alam M, Yoo SS, Walton RL Barbed sutures: a review of the literature. Plast Reconstr Surg. 2008 Mar;121(3):102e-108e. doi: 10.1097/01.prs.0000299452.24743.65. Review.
Barbed vs Standard Suture for Laparoscopic Vaginal Cuff Closure
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
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