Clinical trial NCT03702803 - References

Generalized Anxiety Disorder — Efficacy and Safety Study of a IMSS Developed Phytopharmaceutical for the Treatment of Anxiety.

Citation(s)

•   Abarca Vargas R, Zamilpa A, Aguilar FA, Herrera-Ruiz M, Tortoriello J, Jiménez-Ferrer E
  Pharmacokinetic study in mice of galphimine-A, an anxiolytic compound from Galphimia glauca. Molecules. 2014 Mar 12;19(3):3120-34. doi: 10.3390/molecules19033120.
•   Aguilar-Santamaría L, Ramírez G, Herrera-Arellano A, Zamilpa A, Jiménez JE, Alonso-Cortés D, Cortés-Gutiérrez EI, Ledesma N, Tortoriello J
  Toxicological and cytotoxic evaluation of standardized extracts of Galphimia glauca. J Ethnopharmacol. 2007 Jan 3;1
•   González-Cortazar M, Herrera-Ruiz M, Zamilpa A, Jiménez-Ferrer E, Marquina S, Alvarez L, Tortoriello J
  Anti-inflammatory activity and chemical profile of Galphimia glauca. Planta Med. 2014 Jan;80(1):90-6. doi: 10.1055/s-0033-1360150. Epub 2013 Dec 11.
•   González-Cortazar M, Tortoriello J, Alvarez L
  Norsecofriedelanes as spasmolytics, advances of structure-activity relationships. Planta Med. 2005 Aug;71(8):711-6.
•   Herrera-Arellano A, Jiménez-Ferrer E, Zamilpa A, Morales-Valdéz M, García-Valencia CE, Tortoriello J
  Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder. A randomized, double-blind clinical tri
•   Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J
  Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012 Sep;78(
•   Herrera-Ruiz M, González-Cortazar M, Jiménez-Ferrer E, Zamilpa A, Alvarez L, Ramírez G, Tortoriello J
  Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives. J Nat Prod. 2006 Jan;69(1):59-61. Erratum in: J Nat Prod.
•   Herrera-Ruiz M, Jiménez-Ferrer JE, De Lima TC, Avilés-Montes D, Pérez-García D, González-Cortazar M, Tortoriello J
  Anxiolytic and antidepressant-like activity of a standardized extract from Galphimia glauca. Phytomedicine. 2006 Jan;13(1-2):23-8. Epub 200
•   Jiménez-Ferrer E, Herrera-Ruiz M, Ramírez-García R, Herrera-Arellano A, Tortoriello J
  Interaction of the natural anxiolytic Galphimine-B with serotonergic drugs on dorsal hippocampus in rats. J Ethnopharmacol. 2011 Sep 1;137(1):724-9. doi: 10.1016/j.jep.
•   Jiménez-Ferrer E, Santillán-Urquiza MA, Alegría-Herrera E, Zamilpa A, Noguerón-Merino C, Tortoriello J, Navarro-García V, Avilés-Flores M, Fuentes-Mata M, Herrera-Ruiz M
  Anxiolytic effect of fatty acids and terpenes fraction from Aloysia triphylla: Serot
•   Mangas S, Bonfill M, Osuna L, Moyano E, Tortoriello J, Cusido RM, Piñol MT, Palazón J
  The effect of methyl jasmonate on triterpene and sterol metabolisms of Centella asiatica, Ruscus aculeatus and Galphimia glauca cultured plants. Phytochemistry. 2006 Se
•   Osuna L, Moyano E, Mangas S, Bonfill M, Cusidó RM, Piñol MT, Zamilpa A, Tortoriello J, Palazón J
  Immobilization of Galphimia glauca plant cell suspensions for the production of enhanced amounts of Galphimine-B. Planta Med. 2008 Jan;74(1):94-9. doi: 10.10
•   Osuna L, Pereda-Miranda R, Tortoriello J, Villarreal ML
  Production of the sedative triterpene galphimine B in Galphimia glauca tissue culture. Planta Med. 1999 Mar;65(2):149-52.
•   Prieto-Gómez B, Tortoriello J, Vázquez-Alvarez A, Reyes-Vázquez C
  Galphimine B modulates synaptic transmission on dopaminergic ventral tegmental area neurons. Planta Med. 2003 Jan;69(1):38-43.
•   Rojas G, Aranda E, Navarro V, Zamilpa A, Tortoriello J
  In vitro propagation of Galphimia glauca and content of the sedative compound galphimine-B in wild and micropropagated plants. Planta Med. 2005 Nov;71(11):1076-8.
•   Santillán-Urquiza MA, Herrera-Ruiz M, Zamilpa A, Jiménez-Ferrer E, Román-Ramos R, Tortoriello J
  Pharmacological interaction of Galphimia glauca extract and natural galphimines with Ketamine and Haloperidol on different behavioral tests. Biomed Pharmacoth
•   Tortoriello J, Lozoya X
  Effect of Galphimia glauca methanolic extract on neuropharmacological tests. Planta Med. 1992 Jun;58(3):234-6.
•   Tortoriello J, Ortega A, Herrera-Ruíz M, Trujillo J, Reyes-Vázquez C
  Galphimine-B modifies electrical activity of ventral tegmental area neurons in rats. Planta Med. 1998 May;64(4):309-13.
•   Tortoriello J, Ortega A
  Sedative effect of galphimine B, a nor-seco-triterpenoid from Galphimia glauca. Planta Med. 1993 Oct;59(5):398-400.

Efficacy and Safety Study of a IMSS Developed Phytopharmaceutical for the Treatment of Anxiety. Double Blind and Randomized Clinical Trial Controlled With Alprazolam

Details for clinical trial NCT03702803