Clinical trial NCT01855971 - References

Fragile X Syndrome — "Using Epigallocatechin Gallate (EGCG) and Cognitive Training to Modulate Cognitive Performance in Patients With Fragile X Syndrome" (TESFX)

Citation(s)

•   Adachi N, Tomonaga S, Tachibana T, Denbow DM, Furuse M
  (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain. Eur J Pharmacol. 2006 Feb 15;531(1-3):171-5. Epub 2006 Feb 2.
•   Berry-Kravis E, Knox A, Hervey C
  Targeted treatments for fragile X syndrome. J Neurodev Disord. 2011 Sep;3(3):193-210. doi: 10.1007/s11689-011-9074-7. Epub 2011 Feb 19.
•   Campbell EL, Chebib M, Johnston GA
  The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. Biochem Pharmacol. 2004 Oct 15;68(8):1631-8.
•   Gross C, Berry-Kravis EM, Bassell GJ
  Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond. Neuropsychopharmacology. 2012 Jan;37(1):178-95. doi: 10.1038/npp.2011.137. Epub 2011 Jul 27. Review.
•   Levenga J, de Vrij FM, Oostra BA, Willemsen R
  Potential therapeutic interventions for fragile X syndrome. Trends Mol Med. 2010 Nov;16(11):516-27. doi: 10.1016/j.molmed.2010.08.005. Epub 2010 Sep 21. Review.
•   Van Aller GS, Carson JD, Tang W, Peng H, Zhao L, Copeland RA, Tummino PJ, Luo L
  Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor. Biochem Biophys Res Commun. 2011 Mar 11;406(2):194-9. doi: 10.1016/j.bbrc.2011.02.010. Epub 2011 Feb 15.
•   Verkerk AJ, Pieretti M, Sutcliffe JS, Fu YH, Kuhl DP, Pizzuti A, Reiner O, Richards S, Victoria MF, Zhang FP, et al
  Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell. 1991 May 31;65(5):905-14.
•   Vignes M, Maurice T, Lanté F, Nedjar M, Thethi K, Guiramand J, Récasens M
  Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG). Brain Res. 2006 Sep 19;1110(1):102-15. Epub 2006 Jul 21.
•   Yang J, Han Y, Sun H, Chen C, He D, Guo J, Yu C, Jiang B, Zhou L, Zeng C
  (-)-Epigallocatechin gallate suppresses proliferation of vascular smooth muscle cells induced by high glucose by inhibition of PKC and ERK1/2 signalings. J Agric Food Chem. 2011 Nov 9;59(21):11483-90. doi: 10.1021/jf2024819. Epub 2011 Oct 14.

Estrogen Receptors Beta (ER-B) as Therapeutic Targets for the Improvement of Cognitive Performance in Fragile-X (TESXF)

Details for clinical trial NCT01855971