Clinical trial NCT05567653 - References

Fatigue — Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers

Citation(s)

•   Acharya N, Penukonda S, Shcheglova T, Hagymasi AT, Basu S, Srivastava PK
  Endocannabinoid system acts as a regulator of immune homeostasis in the gut. Proc Natl Acad Sci U S A. 2017 May 9;114(19):5005-5010. doi: 10.1073/pnas.1612177114. Epub 2017 Apr 24.
•   Alhouayek M, Lambert DM, Delzenne NM, Cani PD, Muccioli GG
  Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. FASEB J. 2011 Aug;25(8):2711-21. doi: 10.1096/fj.10-176602. Epub 2011 May 6.
•   Alhouayek M, Muccioli GG
  COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. Trends Pharmacol Sci. 2014 Jun;35(6):284-92. doi: 10.1016/j.tips.2014.03.001. Epub 2014 Mar 29. Review.
•   Biernacki M, Skrzydlewska E
  Metabolism of endocannabinoids. Postepy Hig Med Dosw (Online). 2016 Aug 11;70(0):830-43. Review.
•   Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R
  Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008 Jun;57(6):1470-81. doi: 10.2337/db07-1403. Epub 2008 Feb 27.
•   Cani PD, Plovier H, Van Hul M, Geurts L, Delzenne NM, Druart C, Everard A
  Endocannabinoids--at the crossroads between the gut microbiota and host metabolism. Nat Rev Endocrinol. 2016 Mar;12(3):133-43. doi: 10.1038/nrendo.2015.211. Epub 2015 Dec 18. Review.
•   Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, Geurts L, Naslain D, Neyrinck A, Lambert DM, Muccioli GG, Delzenne NM
  Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut. 2009 Aug;58(8):1091-103. doi: 10.1136/gut.2008.165886. Epub 2009 Feb 24.
•   Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Peña AG, Goodrich JK, Gordon JI, Huttley GA, Kelley ST, Knights D, Koenig JE, Ley RE, Lozupone CA, McDonald D, Muegge BD, Pirrung M, Reeder J, Sevinsky JR, Turnbaugh PJ, Walters WA, Widmann J, Yatsunenko T, Zaneveld J, Knight R
  QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010 May;7(5):335-6. doi: 10.1038/nmeth.f.303. Epub 2010 Apr 11.
•   Castillo PE, Younts TJ, Chávez AE, Hashimotodani Y
  Endocannabinoid signaling and synaptic function. Neuron. 2012 Oct 4;76(1):70-81. doi: 10.1016/j.neuron.2012.09.020. Review.
•   Cheng YH, Ho MS, Huang WT, Chou YT, King K
  Modulation of Glucagon-like Peptide-1 (GLP-1) Potency by Endocannabinoid-like Lipids Represents a Novel Mode of Regulating GLP-1 Receptor Signaling. J Biol Chem. 2015 Jun 5;290(23):14302-13. doi: 10.1074/jbc.M115.655662. Epub 2015 Apr 22.
•   Colín-González AL, Aguilera G, Santamaría A
  Cannabinoids: Glutamatergic Transmission and Kynurenines. Adv Neurobiol. 2016;12:173-98. doi: 10.1007/978-3-319-28383-8_10. Review.
•   Crowe MS, Nass SR, Gabella KM, Kinsey SG
  The endocannabinoid system modulates stress, emotionality, and inflammation. Brain Behav Immun. 2014 Nov;42:1-5. doi: 10.1016/j.bbi.2014.06.007. Epub 2014 Jun 19. Review.
•   Derrien M, Vaughan EE, Plugge CM, de Vos WM
  Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol. 2004 Sep;54(Pt 5):1469-1476. doi: 10.1099/ijs.0.02873-0.
•   Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD
  Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71. doi: 10.1073/pnas.1219451110. Epub 2013 May 13.
•   Everard A, Geurts L, Caesar R, Van Hul M, Matamoros S, Duparc T, Denis RG, Cochez P, Pierard F, Castel J, Bindels LB, Plovier H, Robine S, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD
  Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. Nat Commun. 2014 Dec 5;5:5648. doi: 10.1038/ncomms6648.
•   Fitzgibbon M, Finn DP, Roche M
  High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity. Int J Neuropsychopharmacol. 2015 Sep 5;19(3):pyv095. doi: 10.1093/ijnp/pyv095. Review.
•   Forteza F, Giorgini G, Raymond F
  Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome. Cells. 2021 Apr 17;10(4). pii: 938. doi: 10.3390/cells10040938. Review.
•   Guida F, Turco F, Iannotta M, De Gregorio D, Palumbo I, Sarnelli G, Furiano A, Napolitano F, Boccella S, Luongo L, Mazzitelli M, Usiello A, De Filippis F, Iannotti FA, Piscitelli F, Ercolini D, de Novellis V, Di Marzo V, Cuomo R, Maione S
  Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice. Brain Behav Immun. 2018 Jan;67:230-245. doi: 10.1016/j.bbi.2017.09.001. Epub 2017 Sep 7.
•   Haroon E, Welle JR, Woolwine BJ, Goldsmith DR, Baer W, Patel T, Felger JC, Miller AH
  Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression. Neuropsychopharmacology. 2020 May;45(6):998-1007. doi: 10.1038/s41386-020-0607-1. Epub 2020 Jan 15.
•   Hendry D, Campbell A, Smith A, Hopper L, Straker L, O'Sullivan P
  Movement quantity and quality: How do they relate to pain and disability in dancers? PLoS One. 2022 May 19;17(5):e0268444. doi: 10.1371/journal.pone.0268444. eCollection 2022.
•   Huang WJ, Chen WW, Zhang X
  Endocannabinoid system: Role in depression, reward and pain control (Review). Mol Med Rep. 2016 Oct;14(4):2899-903. doi: 10.3892/mmr.2016.5585. Epub 2016 Aug 1. Review.
•   Lee Y, Jo J, Chung HY, Pothoulakis C, Im E
  Endocannabinoids in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G655-G666. doi: 10.1152/ajpgi.00294.2015. Epub 2016 Aug 18. Review.
•   Lin TW, Kuo YM
  Exercise benefits brain function: the monoamine connection. Brain Sci. 2013 Jan 11;3(1):39-53. doi: 10.3390/brainsci3010039.
•   Mackie K, Stella N
  Cannabinoid receptors and endocannabinoids: evidence for new players. AAPS J. 2006 Apr 28;8(2):E298-306. Review.
•   Manca C, Boubertakh B, Leblanc N, Deschênes T, Lacroix S, Martin C, Houde A, Veilleux A, Flamand N, Muccioli GG, Raymond F, Cani PD, Di Marzo V, Silvestri C
  Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling. J Lipid Res. 2020 Jan;61(1):70-85. doi: 10.1194/jlr.RA119000424. Epub 2019 Nov 5.
•   McBride C, Bronner S
  Injury characteristics in professional modern dancers: A 15-year analysis of work-related injury rates and patterns. J Sports Sci. 2022 Apr;40(7):821-837. doi: 10.1080/02640414.2021.2021030. Epub 2022 Jan 31.
•   Monda V, Villano I, Messina A, Valenzano A, Esposito T, Moscatelli F, Viggiano A, Cibelli G, Chieffi S, Monda M, Messina G
  Exercise Modifies the Gut Microbiota with Positive Health Effects. Oxid Med Cell Longev. 2017;2017:3831972. doi: 10.1155/2017/3831972. Epub 2017 Mar 5. Review.
•   Muccioli GG, Naslain D, Bäckhed F, Reigstad CS, Lambert DM, Delzenne NM, Cani PD
  The endocannabinoid system links gut microbiota to adipogenesis. Mol Syst Biol. 2010 Jul;6:392. doi: 10.1038/msb.2010.46.
•   Nagy-Grócz G, Zádor F, Dvorácskó S, Bohár Z, Benyhe S, Tömböly C, Párdutz Á, Vécsei L
  Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine. Int J Mol Sci. 2017 Jul 30;18(8). pii: E1617. doi: 10.3390/ijms18081617. Review.
•   Nunes AC, Mendes LA, Mota LA, Lima PO, Almeida GP
  Training Load, Pain Intensity, and Functioning Can Explain Injuries in Dancers: A Classification and Regression Tree (CART) Analysis. Med Probl Perform Art. 2022 Jun;37(2):73-77. doi: 10.21091/mppa.2022.2012.
•   Purton T, Staskova L, Lane MM, Dawson SL, West M, Firth J, Clarke G, Cryan JF, Berk M, O'Neil A, Dean O, Hadi A, Honan C, Marx W
  Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis. Neurosci Biobehav Rev. 2021 Apr;123:1-13. doi: 10.1016/j.neubiorev.2020.12.026. Epub 2021 Jan 19. Review.
•   Round JL, Mazmanian SK
  The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009 May;9(5):313-23. doi: 10.1038/nri2515. Review. Erratum in: Nat Rev Immunol. 2009 Aug;9(8):600.
•   Rousseaux C, Thuru X, Gelot A, Barnich N, Neut C, Dubuquoy L, Dubuquoy C, Merour E, Geboes K, Chamaillard M, Ouwehand A, Leyer G, Carcano D, Colombel JF, Ardid D, Desreumaux P
  Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nat Med. 2007 Jan;13(1):35-7. Epub 2006 Dec 10.
•   Rudzki L, Ostrowska L, Pawlak D, Malus A, Pawlak K, Waszkiewicz N, Szulc A
  Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study. Psychoneuroendocrinology. 2019 Feb;100:213-222. doi: 10.1016/j.psyneuen.2018.10.010. Epub 2018 Oct 16.
•   Russo F, Tolomeo F, Vandelli MA, Biagini G, Paris R, Fulvio F, Laganà A, Capriotti AL, Carbone L, Gigli G, Cannazza G, Citti C
  Kynurenine and kynurenic acid: Two human neuromodulators found in Cannabis sativa L. J Pharm Biomed Anal. 2022 Mar 20;211:114636. doi: 10.1016/j.jpba.2022.114636. Epub 2022 Jan 31.
•   Saary P, Forslund K, Bork P, Hildebrand F
  RTK: efficient rarefaction analysis of large datasets. Bioinformatics. 2017 Aug 15;33(16):2594-2595. doi: 10.1093/bioinformatics/btx206.
•   Shao BZ, Wang SL, Pan P, Yao J, Wu K, Li ZS, Bai Y, Linghu EQ
  Targeting NLRP3 Inflammasome in Inflammatory Bowel Disease: Putting out the Fire of Inflammation. Inflammation. 2019 Aug;42(4):1147-1159. doi: 10.1007/s10753-019-01008-y. Review.
•   Shao BZ, Wei W, Ke P, Xu ZQ, Zhou JX, Liu C
  Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and inhibiting NLRP3 inflammasome. CNS Neurosci Ther. 2014 Dec;20(12):1021-8. doi: 10.1111/cns.12349.
•   Sharkey KA, Wiley JW
  The Role of the Endocannabinoid System in the Brain-Gut Axis. Gastroenterology. 2016 Aug;151(2):252-66. doi: 10.1053/j.gastro.2016.04.015. Epub 2016 Apr 29. Review.
•   Skonieczna-Zydecka K, Jakubczyk K, Maciejewska-Markiewicz D, Janda K, Kazmierczak-Siedlecka K, Kaczmarczyk M, Loniewski I, Marlicz W
  Gut Biofactory-Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review. Nutrients. 2020 Nov 1;12(11). pii: E3369. doi: 10.3390/nu12113369. Review.
•   Smid SD
  Gastrointestinal endocannabinoid system: multifaceted roles in the healthy and inflamed intestine. Clin Exp Pharmacol Physiol. 2008 Nov;35(11):1383-7. doi: 10.1111/j.1440-1681.2008.05016.x. Epub 2008 Jul 29. Review.
•   van Winden D, van Rijn RM, Savelsbergh GJP, Oudejans RRD, Stubbe JH
  The Association Between Stress and Injury: A Prospective Cohort Study Among 186 First-Year Contemporary Dance Students. Front Psychol. 2021 Nov 5;12:770494. doi: 10.3389/fpsyg.2021.770494. eCollection 2021.
•   Wang X, He G, Peng Y, Zhong W, Wang Y, Zhang B
  Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway. Sci Rep. 2015 Aug 3;5:12676. doi: 10.1038/srep12676.
•   Wright KL, Duncan M, Sharkey KA
  Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation. Br J Pharmacol. 2008 Jan;153(2):263-70. Epub 2007 Oct 1. Review.
•   Yu W, Jin G, Zhang J, Wei W
  Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome. Inflammation. 2019 Jun;42(3):904-914. doi: 10.1007/s10753-018-0945-x.

Effects of 3-month Probiotic Mix Supplementation (L. Helveticus R-0052, B. Longum R-0175) on Gut Microbiota and Metabolome, Endocannabinoid and Immune Systems Activation, Along With Symptoms of Fatigue in Professional Dancers

Details for clinical trial NCT05567653