NCT03080636 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Cote AT, Bredin SS, Phillips AA, Koehle MS, Warburton DE
Greater autonomic modulation during post-exercise hypotension following high-intensity interval exercise in endurance-trained men and women. Eur J Appl Physiol. 2015 Jan;115(1):81-9. doi: 10.1007/s00421-014-2996-5.
Gomes Anunciação P, Doederlein Polito M
A review on post-exercise hypotension in hypertensive individuals. Arq Bras Cardiol. 2011 May;96(5):e100-109. Review. English, Portuguese, Spanish.
Halliwill JR, Buck TM, Lacewell AN, Romero SA
Postexercise hypotension and sustained postexercise vasodilatation: what happens after we exercise? Exp Physiol. 2013 Jan;98(1):7-18. doi: 10.1113/expphysiol.2011.058065. Review.
Heart rate variability
Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J. 1996 Mar;17(3):354-81.
Queiroz AC, Rezk CC, Teixeira L, Tinucci T, Mion D, Forjaz CL
Gender influence on post-resistance exercise hypotension and hemodynamics. Int J Sports Med. 2013 Nov;34(11):939-44. doi: 10.1055/s-0033-1337948.

Sex and Exercise-mode Differences in Post Exercise Blood Pressure and Heart Rate Variability Responses During Workday

Clinical trial NCT03080636 - References