Clinical trial NCT04183062 - References

Ewing's Sarcoma Metastatic — BIO-11006 for Osteosarcoma and Ewing's Sarcoma Lung Metastases

Citation(s)

•   Blackshear PJ
  The MARCKS family of cellular protein kinase C substrates. J Biol Chem. 1993 Jan 25;268(3):1501-4. Review.
•   Brown HK, Schiavone K, Gouin F, Heymann MF, Heymann D
  Biology of Bone Sarcomas and New Therapeutic Developments. Calcif Tissue Int. 2018 Feb;102(2):174-195. doi: 10.1007/s00223-017-0372-2. Epub 2017 Dec 13. Review.
•   Green TD, Park J, Yin Q, Fang S, Crews AL, Jones SL, Adler KB
  Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein. J Leukoc Biol. 2012 Sep;92(3):633-9. doi: 10.1189/jlb.1211604. Epub 2012 May 23.
•   Grohar PJ, Janeway KA, Mase LD, Schiffman JD
  Advances in the Treatment of Pediatric Bone Sarcomas. Am Soc Clin Oncol Educ Book. 2017;37:725-735. doi: 10.14694/EDBK_175378. Review.
•   Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A
  MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature. 1992 Apr 16;356(6370):618-22.
•   Singer M, Martin LD, Vargaftig BB, Park J, Gruber AD, Li Y, Adler KB
  A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma. Nat Med. 2004 Feb;10(2):193-6. Epub 2004 Jan 11.

A Phase 2 Study of the Safety and Efficacy of BIO-11006 in the Treatment of Recurrent Osteosarcoma and Ewing's Sarcoma in Patients With Lung Metastases

Details for clinical trial NCT04183062