Epilepsy — Computational Neuroscience of Language Processing in the Human Brain
Citation(s)
Blank I, Balewski Z, Mahowald K, Fedorenko E Syntactic processing is distributed across the language system. Neuroimage. 2016 Feb 15;127:307-323. doi: 10.1016/j.neuroimage.2015.11.069. Epub 2015 Dec 5.
Blank IA, Fedorenko E No evidence for differences among language regions in their temporal receptive windows. Neuroimage. 2020 Oct 1;219:116925. doi: 10.1016/j.neuroimage.2020.116925. Epub 2020 May 11.
Fedorenko E, Behr MK, Kanwisher N Functional specificity for high-level linguistic processing in the human brain. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16428-33. doi: 10.1073/pnas.1112937108. Epub 2011 Sep 1.
Fedorenko E, Blank IA Broca's Area Is Not a Natural Kind. Trends Cogn Sci. 2020 Apr;24(4):270-284. doi: 10.1016/j.tics.2020.01.001. Epub 2020 Feb 20.
Fedorenko E, Duncan J, Kanwisher N Language-selective and domain-general regions lie side by side within Broca's area. Curr Biol. 2012 Nov 6;22(21):2059-62. doi: 10.1016/j.cub.2012.09.011. Epub 2012 Oct 11.
Fedorenko E, Nieto-Castanon A, Kanwisher N Lexical and syntactic representations in the brain: an fMRI investigation with multi-voxel pattern analyses. Neuropsychologia. 2012 Mar;50(4):499-513. doi: 10.1016/j.neuropsychologia.2011.09.014. Epub 2011 Sep 17.
Nieto-Castanon A, Fedorenko E Subject-specific functional localizers increase sensitivity and functional resolution of multi-subject analyses. Neuroimage. 2012 Nov 15;63(3):1646-69. doi: 10.1016/j.neuroimage.2012.06.065. Epub 2012 Jul 8.
Norman-Haignere S, Kanwisher NG, McDermott JH Distinct Cortical Pathways for Music and Speech Revealed by Hypothesis-Free Voxel Decomposition. Neuron. 2015 Dec 16;88(6):1281-1296. doi: 10.1016/j.neuron.2015.11.035.
Shain C, Blank IA, van Schijndel M, Schuler W, Fedorenko E fMRI reveals language-specific predictive coding during naturalistic sentence comprehension. Neuropsychologia. 2020 Feb 17;138:107307. doi: 10.1016/j.neuropsychologia.2019.107307. Epub 2019 Dec 24.
Siegelman M, Blank IA, Mineroff Z, Fedorenko E An Attempt to Conceptually Replicate the Dissociation between Syntax and Semantics during Sentence Comprehension. Neuroscience. 2019 Aug 10;413:219-229. doi: 10.1016/j.neuroscience.2019.06.003. Epub 2019 Jun 11.
Computational Neuroscience of Language Processing in the Human Brain
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
