Chasiotis D Role of cyclic AMP and inorganic phosphate in the regulation of muscle glycogenolysis during exercise. Med Sci Sports Exerc. 1988 Dec;20(6):545-50.
Czuba M, Zajac A, Poprzecki S, Cholewa J, Woska S Effects of Sodium Phosphate Loading on Aerobic Power and Capacity in off Road Cyclists. J Sports Sci Med. 2009 Dec 1;8(4):591-9. eCollection 2009.
Di Caprio G, Stokes C, Higgins JM, Schonbrun E Single-cell measurement of red blood cell oxygen affinity. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9984-9. doi: 10.1073/pnas.1509252112. Epub 2015 Jul 27.
Folland JP, Stern R, Brickley G Sodium phosphate loading improves laboratory cycling time-trial performance in trained cyclists. J Sci Med Sport. 2008 Sep;11(5):464-8. Epub 2007 Jun 14.
Galloway SD, Tremblay MS, Sexsmith JR, Roberts CJ The effects of acute phosphate supplementation in subjects of different aerobic fitness levels. Eur J Appl Physiol Occup Physiol. 1996;72(3):224-30.
Khattab M, Abi-Rashed C, Ghattas H, Hlais S, Obeid O Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment. Nutr J. 2015 Oct 29;14:112. doi: 10.1186/s12937-015-0101-5.
Kopec BJ, Dawson BT, Buck C, Wallman KE Effects of sodium phosphate and caffeine ingestion on repeated-sprint ability in male athletes. J Sci Med Sport. 2016 Mar;19(3):272-6. doi: 10.1016/j.jsams.2015.04.001. Epub 2015 Apr 24.
Lichtman MA, Miller DR, Cohen J, Waterhouse C Reduced red cell glycolysis, 2, 3-diphosphoglycerate and adenosine triphosphate concentration, and increased hemoglobin-oxygen affinity caused by hypophosphatemia. Ann Intern Med. 1971 Apr;74(4):562-8.
Xie W, Tran TL, Finegood DT, van de Werve G Dietary P(i) deprivation in rats affects liver cAMP, glycogen, key steps of gluconeogenesis and glucose production. Biochem J. 2000 Nov 15;352 Pt 1:227-32.
Workload of Water Polo Players Following a Phosphorus Manipulated High Carbohydrate Meal
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
