Edentulous Mouth — Complete Lower Dentures on 1 or 2 Implants
Citation(s)
Bryant SR, Walton JN, MacEntee MI A 5-year randomized trial to compare 1 or 2 implants for implant overdentures. J Dent Res. 2015 Jan;94(1):36-43. doi: 10.1177/0022034514554224. Epub 2014 Oct 27.
Gonda T, Maeda Y, Walton JN, MacEntee MI Fracture incidence in mandibular overdentures retained by one or two implants. J Prosthet Dent. 2010 Mar;103(3):178-81. doi: 10.1016/S0022-3913(10)60026-1.
Walton JN, Glick N, Macentee MI A randomized clinical trial comparing patient satisfaction and prosthetic outcomes with mandibular overdentures retained by one or two implants. Int J Prosthodont. 2009 Jul-Aug;22(4):331-9.
Walton JN, MacEntee MI Choosing or refusing oral implants: a prospective study of edentulous volunteers for a clinical trial. Int J Prosthodont. 2005 Nov-Dec;18(6):483-8.
Walton JN, MacEntee MI Screening and enrolling subjects in a randomized clinical trial involving implant dentures. Int J Prosthodont. 2008 May-Jun;21(3):210-4.
A Randomized Clinical Trial Comparing Patient Satisfaction and Prosthetic Outcomes With Mandibular Implant Overdentures Retained by 1 or 2 Implants
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
