Atopic Eczema — A Pilot Study of Efficacy and Safety of SIM05 in Adults With Atopic Eczema
Citation(s)
Burr S Assessment and management of eczema in adults in the community setting. Br J Community Nurs. 2019 Mar 2;24(3):110-115. doi: 10.12968/bjcn.2019.24.3.110. No abstract available.
Chan CX, Zug KA Diagnosis and Management of Dermatitis, Including Atopic, Contact, and Hand Eczemas. Med Clin North Am. 2021 Jul;105(4):611-626. doi: 10.1016/j.mcna.2021.04.003.
Cheng NS, Chau JPC, Lo SHS, Choi KC, Hon KLE, Lam PH, Leung TF Effects of a self-efficacy theory-based parental education program on eczema control and parental outcomes. Pediatr Allergy Immunol. 2021 Apr;32(3):535-543. doi: 10.1111/pai.13421. Epub 2020 Dec 4.
Kimata H Modulation of fecal polyamines by viewing humorous films in patients with atopic dermatitis. Eur J Gastroenterol Hepatol. 2010 Jun;22(6):724-8. doi: 10.1097/MEG.0b013e32832e09f1.
Prasanna PHP, Grandison AS, Charalampopoulos D Bifidobacteria in milk products: An overview of physiological and biochemical properties, exopolysaccharide production, selection criteria of milk products and health benefits. Food Res Int 2014;55:247-62.
Quince C, Walker AW, Simpson JT, Loman NJ, Segata N Shotgun metagenomics, from sampling to analysis. Nat Biotechnol. 2017 Sep 12;35(9):833-844. doi: 10.1038/nbt.3935. Erratum In: Nat Biotechnol. 2017 Dec 8;35(12 ):1211.
Silverberg JI, Hanifin JM Adult eczema prevalence and associations with asthma and other health and demographic factors: a US population-based study. J Allergy Clin Immunol. 2013 Nov;132(5):1132-8. doi: 10.1016/j.jaci.2013.08.031. Epub 2013 Oct 4.
Silverberg NB Typical and atypical clinical appearance of atopic dermatitis. Clin Dermatol. 2017 Jul-Aug;35(4):354-359. doi: 10.1016/j.clindermatol.2017.03.007. Epub 2017 Mar 24.
Song H, Yoo Y, Hwang J, Na YC, Kim HS Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis. J Allergy Clin Immunol. 2016 Mar;137(3):852-60. doi: 10.1016/j.jaci.2015.08.021. Epub 2015 Oct 1.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.