NCT03215251 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Arai SR, Butzlaff A, Stotts NA, Puntillo KA
Quench the thirst: lessons from clinical thirst trials. Biol Res Nurs. 2014 Oct;16(4):456-66. doi: 10.1177/1099800413505900. Epub 2013 Oct 16. Review.
Nelson JE, Meier DE, Oei EJ, Nierman DM, Senzel RS, Manfredi PL, Davis SM, Morrison RS
Self-reported symptom experience of critically ill cancer patients receiving intensive care. Crit Care Med. 2001 Feb;29(2):277-82.
Puntillo K, Arai SR, Cooper BA, Stotts NA, Nelson JE
A randomized clinical trial of an intervention to relieve thirst and dry mouth in intensive care unit patients. Intensive Care Med. 2014 Sep;40(9):1295-302. doi: 10.1007/s00134-014-3339-z. Epub 2014 Jun 4.
Stotts NA, Arai SR, Cooper BA, Nelson JE, Puntillo KA
Predictors of thirst in intensive care unit patients. J Pain Symptom Manage. 2015 Mar;49(3):530-8. doi: 10.1016/j.jpainsymman.2014.07.001. Epub 2014 Aug 10.

Experimental Study to Evaluate the Effectiveness of an Intervention Bundle on Thirst Intensity and Dry Mouth Among Patients of Selected Units

Clinical trial NCT03215251 - References