Clinical trial NCT01565759 - References

Drug Mechanism — In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects

Citation(s)

•   Baldessarini RJ, Tondo L
  Does lithium treatment still work? Evidence of stable responses over three decades. Arch Gen Psychiatry. 2000 Feb;57(2):187-90. Review.
•   Bosetti F, Seemann R, Bell JM, Zahorchak R, Friedman E, Rapoport SI, Manickam P
  Analysis of gene expression with cDNA microarrays in rat brain after 7 and 42 days of oral lithium administration. Brain Res Bull. 2002 Jan 15;57(2):205-9.
•   Chen RW, Chuang DM
  Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity. J Biol Chem. 1999 Mar 5;274(10):6039-42.
•   Chetcuti A, Adams LJ, Mitchell PB, Schofield PR
  Microarray gene expression profiling of mouse brain mRNA in a model of lithium treatment. Psychiatr Genet. 2008 Apr;18(2):64-72. doi: 10.1097/YPG.0b013e3282fb0051.
•   Garnham J, Munro A, Slaney C, Macdougall M, Passmore M, Duffy A, O'Donovan C, Teehan A, Alda M
  Prophylactic treatment response in bipolar disorder: results of a naturalistic observation study. J Affect Disord. 2007 Dec;104(1-3):185-90. Epub 2007 Apr 17.
•   Machado-Vieira R, Pivovarova NB, Stanika RI, Yuan P, Wang Y, Zhou R, Zarate CA Jr, Drevets WC, Brantner CA, Baum A, Laje G, McMahon FJ, Chen G, Du J, Manji HK, Andrews SB
  The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder. Biol Psychiatry. 2011 Feb 15;69(4):344-52. doi: 10.1016/j.biopsych.2010.10.019. Epub 2010 Dec 16.
•   McQuillin A, Rizig M, Gurling HM
  A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder. Pharmacogenet Genomics. 2007 Aug;17(8):605-17.
•   Seelan RS, Khalyfa A, Lakshmanan J, Casanova MF, Parthasarathy RN
  Deciphering the lithium transcriptome: microarray profiling of lithium-modulated gene expression in human neuronal cells. Neuroscience. 2008 Feb 19;151(4):1184-97. doi: 10.1016/j.neuroscience.2007.10.045. Epub 2007 Nov 13.
•   Sugawara H, Iwamoto K, Bundo M, Ishiwata M, Ueda J, Kakiuchi C, Ishigooka J, Kato T
  Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm (Vienna). 2010 Feb;117(2):155-64. doi: 10.1007/s00702-009-0340-8. Epub 2009 Dec 1.
•   Sun A, Shanmugam I, Song J, Terranova PF, Thrasher JB, Li B
  Lithium suppresses cell proliferation by interrupting E2F-DNA interaction and subsequently reducing S-phase gene expression in prostate cancer. Prostate. 2007 Jun 15;67(9):976-88.
•   Sun X, Young LT, Wang JF, Grof P, Turecki G, Rouleau GA, Alda M
  Identification of lithium-regulated genes in cultured lymphoblasts of lithium responsive subjects with bipolar disorder. Neuropsychopharmacology. 2004 Apr;29(4):799-804.
•   Tseng M, Alda M, Xu L, Sun X, Wang JF, Grof P, Turecki G, Rouleau G, Young LT
  BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder. J Psychiatry Neurosci. 2008 Sep;33(5):449-53.
•   Uemura T, Green M, Corson TW, Perova T, Li PP, Warsh JJ
  Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder. Bipolar Disord. 2011 Feb;13(1):41-51. doi: 10.1111/j.1399-5618.2011.00897.x.
•   Washizuka S, Iwamoto K, Kakiuchi C, Bundo M, Kato T
  Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. Neurosci Res. 2009 Mar;63(3):199-204. doi: 10.1016/j.neures.2008.12.004. Epub 2008 Dec 24.

Investigation of the Effects of in Vivo Lithium Treatment on Gene Expression Levels Using Lymphoblastoid Cell Lines From Human Healthy Subjects

Details for clinical trial NCT01565759