Bosma-den Boer MM, van Wetten ML, Pruimboom L Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering. Nutr Metab (Lond). 2012 Apr 17;9(1):32. doi: 10.1186/1743-7075-9-32.
Ekici, E , Ikiisik, H. , Ankarali, H. , Manav, G. , Colak, M. & Kozan, E. H. (2021). The validity and reliability of the Turkish version of the Family Nutrition and Physical Activity screening tool . Marmara Medical Journal , 34 (3) , 319-326 . DOI: 10.5472/marumj.1009125
Hujoel P Dietary carbohydrates and dental-systemic diseases. J Dent Res. 2009 Jun;88(6):490-502. doi: 10.1177/0022034509337700.
Ihmels MA, Welk GJ, Eisenmann JC, Nusser SM Development and preliminary validation of a Family Nutrition and Physical Activity (FNPA) screening tool. Int J Behav Nutr Phys Act. 2009 Mar 12;6:14. doi: 10.1186/1479-5868-6-14.
Kim HS, Park JW, Yeo SI, Choi BJ, Suh JY Effects of high glucose on cellular activity of periodontal ligament cells in vitro. Diabetes Res Clin Pract. 2006 Oct;74(1):41-7. doi: 10.1016/j.diabres.2006.03.034. Epub 2006 Jun 30.
Laiola M, De Filippis F, Vitaglione P, Ercolini D A Mediterranean Diet Intervention Reduces the Levels of Salivary Periodontopathogenic Bacteria in Overweight and Obese Subjects. Appl Environ Microbiol. 2020 Jun 2;86(12):e00777-20. doi: 10.1128/AEM.00777
LOE H, SILNESS J PERIODONTAL DISEASE IN PREGNANCY. I. PREVALENCE AND SEVERITY. Acta Odontol Scand. 1963 Dec;21:533-51. doi: 10.3109/00016356309011240. No abstract available.
Pekcan, G (2008). Beslenme durumunun saptanmasi. Diyet El Kitabi, 726, 67-141.
Sahingöz, S A., Özgen, L., & Yalçin, E. (2019). Akdeniz Diyet Kalitesi Ölçeginin (Mediterranean Diet Quality-KIDMED) Geçerlik ve Güvenirlik Çalismasi. Proceedings Book of 5th International Eurasian Congress on Natural Nutrition, Healthy Life & Sport, 1078-1088. 02-06 October 2019, Ankara/Turkey.
SILNESS J, LOE H PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. Acta Odontol Scand. 1964 Feb;22:121-35. doi: 10.3109/00016356408993968. No abstract available.
Sofi F, Abbate R, Gensini GF, Casini A Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr. 2010 Nov;92(5):1189-96. doi: 10.3945/ajcn.2010.29673. Epub 2010 Sep 1.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
