Emery CF, Kiecolt-Glaser JK, Glaser R, Malarkey WB, Frid DJ Exercise accelerates wound healing among healthy older adults: a preliminary investigation. J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1432-6. doi: 10.1093/gerona/60.11.1432.
Eraydin S, Avsar G The Effect of Foot Exercises on Wound Healing in Type 2 Diabetic Patients With a Foot Ulcer: A Randomized Control Study. J Wound Ostomy Continence Nurs. 2018 Mar/Apr;45(2):123-130. doi: 10.1097/WON.0000000000000405.
Keylock T, Young H Delayed wound healing: can exercise accelerate it? International Journal of Exercise Science 3(3): 70-78, 2010.
Matos M, Mendes R, Silva AB, Sousa N Physical activity and exercise on diabetic foot related outcomes: A systematic review. Diabetes Res Clin Pract. 2018 May;139:81-90. doi: 10.1016/j.diabres.2018.02.020. Epub 2018 Feb 23.
Pence BD, DiPietro LA, Woods JA Exercise speeds cutaneous wound healing in high-fat diet-induced obese mice. Med Sci Sports Exerc. 2012 Oct;44(10):1846-54. doi: 10.1249/MSS.0b013e31825a5971.
Riebe D et al. ACSM's Guidelines for Exercise Testing and Prescription 10th ed. Philadelphia (PA). Wolters Kluwer; 2018.
Exercise Enhances Wound Healing in Patients With Diabetic Foot Ulcers
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
