Clinical trial NCT02859116 - References

Diabetes — Collection of Gastrointestinal Tissue Samples for the Characterization and ex Vivo Functional Assessment of Chemoreceptors

Citation(s)

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  Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells. J Biomed Sci. 2003 Nov-Dec;10(6 Pt 2):782-91.
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  Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways. Diabetologia. 2014 Oct;57(10):2117-25. doi: 10.1007/s00125-014-3326-5. Epub 2014 Jul 13. Erratum in: Diabetologia. 2014 Nov;57(11):2428.
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•   Kyriazis GA, Smith KR, Tyrberg B, Hussain T, Pratley RE
  Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice. Endocrinology. 2014 Jun;155(6):2112-21. doi: 10.1210/en.2013-2015. Epub 2014 Apr 8.
•   Kyriazis GA, Soundarapandian MM, Tyrberg B
  Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E524-32. doi: 10.1073/pnas.1115183109. Epub 2012 Feb 6.
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•   Steinert RE, Gerspach AC, Gutmann H, Asarian L, Drewe J, Beglinger C
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•   Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E
  Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2392-7.

Collection of Gastrointestinal Tissue Samples for the Characterization and ex Vivo Functional Assessment of Chemoreceptors

Details for clinical trial NCT02859116