NCT02441504 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Antonios TF, Kaski JC, Hasan KM, Brown SJ, Singer DR
Rarefaction of skin capillaries in patients with anginal chest pain and normal coronary arteriograms. Eur Heart J. 2001 Jul;22(13):1144-8.
Antonios TF, Nama V, Wang D, Manyonda IT
Microvascular remodelling in preeclampsia: quantifying capillary rarefaction accurately and independently predicts preeclampsia. Am J Hypertens. 2013 Sep;26(9):1162-9. doi: 10.1093/ajh/hpt087. Epub 2013 Jun 11.
Gomes MB, Matheus AS, Tibiriçá E
Evaluation of microvascular endothelial function in patients with type 1 diabetes using laser-Doppler perfusion monitoring: which method to choose? Microvasc Res. 2008 Aug;76(2):132-3. doi: 10.1016/j.mvr.2008.04.003. Epub 2008 Apr 25.
Matheus AS, Tibiriçá E, da Silva PB, de Fátima Bevilácqua da Matta M, Gomes MB
Uric acid levels are associated with microvascular endothelial dysfunction in patients with Type 1 diabetes. Diabet Med. 2011 Oct;28(10):1188-93. doi: 10.1111/j.1464-5491.2011.03349.x.
Nama V, Manyonda IT, Onwude J, Antonios TF
Structural capillary rarefaction and the onset of preeclampsia. Obstet Gynecol. 2012 May;119(5):967-74. doi: 10.1097/AOG.0b013e31824ea092.

Effects of Low Intensity Aerobic Exercise Training on the Microvascular Endothelial Function of Patients With Type 1 Diabetes: a Non-pharmacological Interventional Study

Details for clinical trial NCT02441504

Clinical trial NCT02441504 - References