Belujon P, Grace AA Dopamine System Dysregulation in Major Depressive Disorders. Int J Neuropsychopharmacol. 2017 Dec 1;20(12):1036-1046. doi: 10.1093/ijnp/pyx056.
Berridge KC Evolving Concepts of Emotion and Motivation. Front Psychol. 2018 Sep 7;9:1647. doi: 10.3389/fpsyg.2018.01647. eCollection 2018.
Brenhouse HC, Schwarz JM Immunoadolescence: Neuroimmune development and adolescent behavior. Neurosci Biobehav Rev. 2016 Nov;70:288-299. doi: 10.1016/j.neubiorev.2016.05.035. Epub 2016 May 31.
Brundin L, Bryleva EY, Thirtamara Rajamani K Role of Inflammation in Suicide: From Mechanisms to Treatment. Neuropsychopharmacology. 2017 Jan;42(1):271-283. doi: 10.1038/npp.2016.116. Epub 2016 Jul 5.
Connor JR, Menzies SL Relationship of iron to oligodendrocytes and myelination. Glia. 1996 Jun;17(2):83-93. doi: 10.1002/(SICI)1098-1136(199606)17:23.0.CO;2-7.
Craske MG, Meuret AE, Ritz T, Treanor M, Dour H, Rosenfield D Positive affect treatment for depression and anxiety: A randomized clinical trial for a core feature of anhedonia. J Consult Clin Psychol. 2019 May;87(5):457-471. doi: 10.1037/ccp0000396.
Der-Avakian A, Barnes SA, Markou A, Pizzagalli DA Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders. Curr Top Behav Neurosci. 2016;28:231-62. doi: 10.1007/7854_2015_5004.
Der-Avakian A, Markou A The neurobiology of anhedonia and other reward-related deficits. Trends Neurosci. 2012 Jan;35(1):68-77. doi: 10.1016/j.tins.2011.11.005. Epub 2011 Dec 15.
Felger JC, Li Z, Haroon E, Woolwine BJ, Jung MY, Hu X, Miller AH Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Mol Psychiatry. 2016 Oct;21(10):1358-65. doi: 10.1038/mp.2015.168. Epub 2015 Nov 10.
Felger JC, Treadway MT Inflammation Effects on Motivation and Motor Activity: Role of Dopamine. Neuropsychopharmacology. 2017 Jan;42(1):216-241. doi: 10.1038/npp.2016.143. Epub 2016 Aug 2.
Felger JC The Role of Dopamine in Inflammation-Associated Depression: Mechanisms and Therapeutic Implications. Curr Top Behav Neurosci. 2017;31:199-219. doi: 10.1007/7854_2016_13.
Forbes EE, Dahl RE Research Review: altered reward function in adolescent depression: what, when and how? J Child Psychol Psychiatry. 2012 Jan;53(1):3-15. doi: 10.1111/j.1469-7610.2011.02477.x. Epub 2011 Nov 28.
Healey KL, Morgan J, Musselman SC, Olino TM, Forbes EE Social anhedonia and medial prefrontal response to mutual liking in late adolescents. Brain Cogn. 2014 Aug;89:39-50. doi: 10.1016/j.bandc.2013.12.004. Epub 2014 Jan 10.
Hordacre B, Goldsworthy MR, Graetz L, Ridding MC Motor network connectivity predicts neuroplastic response following theta burst stimulation in healthy adults. Brain Struct Funct. 2021 Jul;226(6):1893-1907. doi: 10.1007/s00429-021-02299-4. Epub 2021 May 27.
Larsen B, Luna B In vivo evidence of neurophysiological maturation of the human adolescent striatum. Dev Cogn Neurosci. 2015 Apr;12:74-85. doi: 10.1016/j.dcn.2014.12.003. Epub 2014 Dec 30.
Lin A, Yung AR, Wigman JT, Killackey E, Baksheev G, Wardenaar KJ Validation of a short adaptation of the Mood and Anxiety Symptoms Questionnaire (MASQ) in adolescents and young adults. Psychiatry Res. 2014 Mar 30;215(3):778-83. doi: 10.1016/j.psychres.2013.12.018. Epub 2013 Dec 18.
Miller AH, Raison CL The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol. 2016 Jan;16(1):22-34. doi: 10.1038/nri.2015.5.
Mitchell RH, Goldstein BI Inflammation in children and adolescents with neuropsychiatric disorders: a systematic review. J Am Acad Child Adolesc Psychiatry. 2014 Mar;53(3):274-96. doi: 10.1016/j.jaac.2013.11.013. Epub 2013 Dec 16.
Moeini M, Khaleghi A, Mohammadi MR Characteristics of Alpha Band Frequency in Adolescents with Bipolar II Disorder: A Resting-State QEEG Study. Iran J Psychiatry. 2015;10(1):8-12.
Pizzagalli DA Depression, stress, and anhedonia: toward a synthesis and integrated model. Annu Rev Clin Psychol. 2014;10:393-423. doi: 10.1146/annurev-clinpsy-050212-185606.
Pratt LA, Brody DJ, Gu Q Antidepressant use in persons aged 12 and over: United States, 2005-2008. NCHS Data Brief. 2011 Oct;(76):1-8.
Pulcu E, Guinea C, Cowen PJ, Murphy SE, Harmer CJ A translational perspective on the anti-anhedonic effect of ketamine and its neural underpinnings. Mol Psychiatry. 2022 Jan;27(1):81-87. doi: 10.1038/s41380-021-01183-1. Epub 2021 Jun 22.
Radloff LS The CES-D scale: A self-report depression scale for research in the general population. Applied psychological measurement. 1977;1(3):385-401.
Rajapakse T, Kirton A NON-INVASIVE BRAIN STIMULATION IN CHILDREN: APPLICATIONS AND FUTURE DIRECTIONS. Transl Neurosci. 2013 Jun;4(2):10.2478/s13380-013-0116-3. doi: 10.2478/s13380-013-0116-3.
Rizvi SJ, Pizzagalli DA, Sproule BA, Kennedy SH Assessing anhedonia in depression: Potentials and pitfalls. Neurosci Biobehav Rev. 2016 Jun;65:21-35. doi: 10.1016/j.neubiorev.2016.03.004. Epub 2016 Mar 6.
Wang L, Li F, Mitchell PB, Wang CY, Si TM Striatal Resting-State Connectivity Abnormalities Associated With Different Clinical Stages of Major Depressive Disorder. J Clin Psychiatry. 2020 Feb 18;81(2):19m12790. doi: 10.4088/JCP.19m12790.
Wang Y, Butros SR, Shuai X, Dai Y, Chen C, Liu M, Haacke EM, Hu J, Xu H Different iron-deposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility-weighted imaging. AJNR Am J Neuroradiol. 2012 Feb;33(2):266-73. doi: 10.3174/ajnr.A2765. Epub 2011 Nov 3.
Wengler K, He X, Abi-Dargham A, Horga G Reproducibility assessment of neuromelanin-sensitive magnetic resonance imaging protocols for region-of-interest and voxelwise analyses. Neuroimage. 2020 Mar;208:116457. doi: 10.1016/j.neuroimage.2019.116457. Epub 2019 Dec 11.
Whitton AE, Treadway MT, Pizzagalli DA Reward processing dysfunction in major depression, bipolar disorder and schizophrenia. Curr Opin Psychiatry. 2015 Jan;28(1):7-12. doi: 10.1097/YCO.0000000000000122.
Xing Y, Sapuan A, Dineen RA, Auer DP Life span pigmentation changes of the substantia nigra detected by neuromelanin-sensitive MRI. Mov Disord. 2018 Nov;33(11):1792-1799. doi: 10.1002/mds.27502. Epub 2018 Nov 13.
Zhang WN, Chang SH, Guo LY, Zhang KL, Wang J The neural correlates of reward-related processing in major depressive disorder: a meta-analysis of functional magnetic resonance imaging studies. J Affect Disord. 2013 Nov;151(2):531-539. doi: 10.1016/j.jad.2013.06.039. Epub 2013 Jul 12.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.