Ali MR, Rasmussen JJ, Monash JB, Fuller WD Depression is associated with increased severity of co-morbidities in bariatric surgical candidates. Surg Obes Relat Dis. 2009 Sep-Oct;5(5):559-64. doi: 10.1016/j.soard.2008.10.015. Epub 2008 Nov 21.
Behrns KE, Smith CD, Sarr MG Prospective evaluation of gastric acid secretion and cobalamin absorption following gastric bypass for clinically severe obesity. Dig Dis Sci. 1994 Feb;39(2):315-20.
Bodnar LM, Wisner KL Nutrition and depression: implications for improving mental health among childbearing-aged women. Biol Psychiatry. 2005 Nov 1;58(9):679-85. Epub 2005 Jul 25. Review.
Brolin RE Update: NIH consensus conference. Gastrointestinal surgery for severe obesity. Nutrition. 1996 Jun;12(6):403-4. Review.
Clark MM, Niaura R, King TK, Pera V Depression, smoking, activity level, and health status: pretreatment predictors of attrition in obesity treatment. Addict Behav. 1996 Jul-Aug;21(4):509-13.
Gubbins PO, Bertch KE Drug absorption in gastrointestinal disease and surgery. Clinical pharmacokinetic and therapeutic implications. Clin Pharmacokinet. 1991 Dec;21(6):431-47. Review.
Hanley MJ, Abernethy DR, Greenblatt DJ Effect of obesity on the pharmacokinetics of drugs in humans. Clin Pharmacokinet. 2010;49(2):71-87. doi: 10.2165/11318100-000000000-00000. Review.
Magee SR, Shih G, Hume A Malabsorption of oral antibiotics in pregnancy after gastric bypass surgery. J Am Board Fam Med. 2007 May-Jun;20(3):310-3.
Malinowski SS Nutritional and metabolic complications of bariatric surgery. Am J Med Sci. 2006 Apr;331(4):219-25. Review.
Miller AD, Smith KM Medication and nutrient administration considerations after bariatric surgery. Am J Health Syst Pharm. 2006 Oct 1;63(19):1852-7. Review.
Onyike CU, Crum RM, Lee HB, Lyketsos CG, Eaton WW Is obesity associated with major depression? Results from the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2003 Dec 15;158(12):1139-47.
Padwal R, Brocks D, Sharma AM A systematic review of drug absorption following bariatric surgery and its theoretical implications. Obes Rev. 2010 Jan;11(1):41-50. doi: 10.1111/j.1467-789X.2009.00614.x. Epub 2009 Jun 2. Review.
Reis M, Aberg-Wistedt A, Agren H, Akerblad AC, Bengtsson F Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations. J Affect Disord. 2004 Nov 1;82(3):443-6.
Roerig JL, Steffen K, Zimmerman C, Mitchell JE, Crosby RD, Cao L Preliminary comparison of sertraline levels in postbariatric surgery patients versus matched nonsurgical cohort. Surg Obes Relat Dis. 2012 Jan-Feb;8(1):62-6. doi: 10.1016/j.soard.2010.12.003. Epub 2010 Dec 15.
Rusch MD, Andris D Maladaptive eating patterns after weight-loss surgery. Nutr Clin Pract. 2007 Feb;22(1):41-9. Review.
Serretti A, Mandelli L Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry. 2010 Oct;71(10):1259-72. doi: 10.4088/JCP.09r05346blu. Review.
Williams JBW, Terman M Structured Interview Guide for the Hamilton Depression Rating Scale with Ayptical Depression Supplement (SIGH-ADS). New York: New York State Psychiatric Institute; 2003.
Wills SM, Zekman R, Bestul D, Kuwajerwala N, Decker D Tamoxifen malabsorption after Roux-en-Y gastric bypass surgery: case series and review of the literature. Pharmacotherapy. 2010 Feb;30(2):217. doi: 10.1592/phco.30.2.217. Review.
The Effect of Gastric Bypass on the Pharmacokinetics of Serotonin Reuptake Inhibitors
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
