Depression — Collaborative Care Model for the Treatment of Persistent Symptoms After Concussion Among Youth
Citation(s)
Johnson AM, McCarty CA, Marcynyszyn LA, Zatzick DF, Chrisman SP, Rivara FP Child- compared with parent-report ratings on psychosocial measures following a mild traumatic brain injury among youth with persistent post-concussion symptoms. Brain Inj. 2021 Mar 18:1-13. doi: 10.1080/02699052.2021.1889663. [Epub ahead of print]
Marcynyszyn LA, McCarty CA, Rivara FP, Johnson AM, Wang J, Zatzick DF Parent Traumatic Events and Adolescent Internalizing Symptoms: The Mediating Role of Parental Depression Among Youth with Persistent Postconcussive Symptoms. J Pediatr Psychol. 2021 Jan 7. pii: jsaa128. doi: 10.1093/jpepsy/jsaa128. [Epub ahead of print]
McCarty CA, Zatzick D, Hoopes T, Payne K, Parrish R, Rivara FP Collaborative care model for treatment of persistent symptoms after concussion among youth (CARE4PCS-II): Study protocol for a randomized, controlled trial. Trials. 2019 Sep 18;20(1):567. doi: 10.1186/s13063-019-3662-3.
Payne KM, Prentice ET, Marcynyszyn LA, McCarty CA Goals for Persistent Postconcussive Symptom Treatment From Adolescent and Parent Perspectives. JAMA Pediatr. 2020 May 11. doi: 10.1001/jamapediatrics.2020.0898. [Epub ahead of print]
Collaborative Care Model for the Treatment of Persistent Symptoms After Concussion Among Youth
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
