Christensen H, Griffiths K, Groves C, Korten A Free range users and one hit wonders: community users of an Internet-based cognitive behaviour therapy program. Aust N Z J Psychiatry. 2006 Jan;40(1):59-62. doi: 10.1080/j.1440-1614.2006.01743.x.
Duffecy, J , Cai, X., & Mohr, D. C. (2013). Supportive accountability: Measurement of a framework for adherence to behavioral intervention technologies. International Society for Research on Internet Interventions, Chicago, IL.
Eysenbach G The law of attrition. J Med Internet Res. 2005 Mar 31;7(1):e11. doi: 10.2196/jmir.7.1.e11.
First, M B., Williams, J. B. W., Karg, R. S., & Spitzer, R. L. (2015). Structured clinical interview for DSM-5 disorders, clinician version (SCID-5-CV). Arlington, VA: American Psychiatric Association.
Gorka SM, Burkhouse KL, Afshar K, Phan KL Error-related brain activity and internalizing disorder symptom dimensions in depression and anxiety. Depress Anxiety. 2017 Nov;34(11):985-995. doi: 10.1002/da.22648. Epub 2017 Sep 20.
Johnston L, Titov N, Andrews G, Dear BF, Spence J Comorbidity and internet-delivered transdiagnostic cognitive behavioural therapy for anxiety disorders. Cogn Behav Ther. 2013;42(3):180-92. doi: 10.1080/16506073.2012.753108. Epub 2013 Mar 4.
Kelders SM, Bohlmeijer ET, Pots WT, van Gemert-Pijnen JE Comparing human and automated support for depression: Fractional factorial randomized controlled trial. Behav Res Ther. 2015 Sep;72:72-80. doi: 10.1016/j.brat.2015.06.014. Epub 2015 Jul 6.
Kirkpatrick T, Manoukian L, Dear BF, Johnston L, Titov N A feasibility open trial of internet-delivered cognitive-behavioural therapy (iCBT) among consumers of a non-governmental mental health organisation with anxiety. PeerJ. 2013 Nov 28;1:e210. doi: 10.7717/peerj.210. eCollection 2013.
Kroenke K, Spitzer RL, Williams JB, Monahan PO, Lowe B Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection. Ann Intern Med. 2007 Mar 6;146(5):317-25. doi: 10.7326/0003-4819-146-5-200703060-00004.
Lovibond PF, Lovibond SH The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behav Res Ther. 1995 Mar;33(3):335-43. doi: 10.1016/0005-7967(94)00075-u.
Lovibond, S H., & Lovibond, P. F. (1993). Manual for the Depression Anxiety Stress Scales (DASS). Psychology Foundation Monograph, University of New South Wales.
MacArthur Foundation's Initiative (2004) The Macarthur initiative on depression and primary care at Dartmouth and Duke: Depression management toolkit. Hanover, NH: Dartmouth.
Miner AS, Schueller SM, Lattie EG, Mohr DC Creation and validation of the Cognitive and Behavioral Response to Stress Scale in a depression trial. Psychiatry Res. 2015 Dec 30;230(3):819-25. doi: 10.1016/j.psychres.2015.10.033. Epub 2015 Oct 30.
Munoz RF, Aguilera A, Schueller SM, Leykin Y, Perez-Stable EJ From online randomized controlled trials to participant preference studies: morphing the San Francisco Stop Smoking site into a worldwide smoking cessation resource. J Med Internet Res. 2012 Jun 27;14(3):e64. doi: 10.2196/jmir.1852.
Munoz RF Using evidence-based internet interventions to reduce health disparities worldwide. J Med Internet Res. 2010 Dec 17;12(5):e60. doi: 10.2196/jmir.1463.
Muñoz, R F., Bunge, E. L., Chen, K., Schueller, S. M., Bravin, J. I., Shaughnessy, E. A., & Pérez- Stable, E. J. (2015). Massive open online interventions: A novel model for delivering behavioral-health services worldwide. Clinical Psychological Science. Advanced Online Publication. http://doi.org/10.1177/2167702615583840
Nguyen, T , O'Dea, B., Larsen, M., Phung, D., Venkatesh, S., & Christensen, H. (2015, November). Differentiating sub-groups of online depression-related communities using textual cues. In International Conference on Web Information Systems Engineering (pp. 216-224). Springer International Publishing.
O'Dea, B , Wan, S., Batterham, P. J., Calear, A. L., Paris, C., & Christensen, H. (2015). Detecting suicidality on Twitter. Internet Interventions, 2(2), 183-188. http://dx.doi.org/10.1016/j.invent.2015.03.005
Preacher KJ, Hayes AF Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods. 2008 Aug;40(3):879-91. doi: 10.3758/brm.40.3.879.
Schueller SM, Mohr DC Initial Field Trial of a Coach-Supported Web-Based Depression Treatment. Int Conf Pervasive Comput Technol Healthc. 2015 Aug;2015:10.4108/icst.pervasivehealth.2015.260115. doi: 10.4108/icst.pervasivehealth.2015.260115. Epub 2015 Aug 3.
van Mierlo T The 1% rule in four digital health social networks: an observational study. J Med Internet Res. 2014 Feb 4;16(2):e33. doi: 10.2196/jmir.2966.
Evaluation of the Crowd-Powered Web Platform for Accumulative Depression and Anxiety Plans and Treatment (ADAPT)
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.