Canli T Reconceptualizing major depressive disorder as an infectious disease. Biol Mood Anxiety Disord. 2014 Oct 21;4:10. doi: 10.1186/2045-5380-4-10. eCollection 2014.
Denton, H and Aranda K. The wellbeing benefits of sea swimming. Is it time to revisit the sea cure? Qualitative Research in Sport, Exercise and Health. 2019. pp. 1-17.
Dugdill L, Graham RC, McNair F Exercise referral: the public health panacea for physical activity promotion? A critical perspective of exercise referral schemes; their development and evaluation. Ergonomics. 2005 Sep 15-Nov 15;48(11-14):1390-410. Review.
Foley R Swimming in Ireland: Immersions in therapeutic blue space. Health Place. 2015 Sep;35:218-25. doi: 10.1016/j.healthplace.2014.09.015.
Gabay C, Kushner I Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999 Feb 11;340(6):448-54. Review. Erratum in: N Engl J Med 1999 Apr 29;340(17):1376.
Hage FG, Szalai AJ C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. J Am Coll Cardiol. 2007 Sep 18;50(12):1115-22. Epub 2007 Sep 4. Review.
Holt-Lunstad J, Smith TB, Layton JB Social relationships and mortality risk: a meta-analytic review. PLoS Med. 2010 Jul 27;7(7):e1000316. doi: 10.1371/journal.pmed.1000316. Review.
Iacobucci G NHS prescribed record number of antidepressants last year. BMJ. 2019 Mar 29;364:l1508. doi: 10.1136/bmj.l1508.
Jones A, Hillsdon M, Coombes E Greenspace access, use, and physical activity: understanding the effects of area deprivation. Prev Med. 2009 Dec;49(6):500-5. doi: 10.1016/j.ypmed.2009.10.012. Epub 2009 Oct 24.
Markanday A Acute Phase Reactants in Infections: Evidence-Based Review and a Guide for Clinicians. Open Forum Infect Dis. 2015 Jul 3;2(3):ofv098. doi: 10.1093/ofid/ofv098. eCollection 2015 Sep. Review.
Murray, C J. L. et al. (1996) 'The Global burden of disease : a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020 : summary / edited by Christopher J. L. Murray, Alan D. Lopez'. Geneva PP - Geneva: World Health Organization (Global burden of disease and injury series, volume 1). Available at: https://apps.who.int/iris/handle/10665/41864.
Pizzo PA A Prescription for Longevity in the 21st Century: Renewing Purpose, Building and Sustaining Social Engagement, and Embracing a Positive Lifestyle. JAMA. 2020 Feb 4;323(5):415-416. doi: 10.1001/jama.2019.21087.
Ridker PM Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003 Jan 28;107(3):363-9. Review.
Tangvarasittichai S, Pongthaisong S, Tangvarasittichai O Tumor Necrosis Factor-?, Interleukin-6, C-Reactive Protein Levels and Insulin Resistance Associated with Type 2 Diabetes in Abdominal Obesity Women. Indian J Clin Biochem. 2016 Mar;31(1):68-74. doi: 10.1007/s12291-015-0514-0. Epub 2015 Jul 26.
van Tulleken C, Tipton M, Massey H, Harper CM Open water swimming as a treatment for major depressive disorder. BMJ Case Rep. 2018 Aug 21;2018. pii: bcr-2018-225007. doi: 10.1136/bcr-2018-225007.
The Effect of a Sea-safety Course on Mood, Mental Wellbeing and Inflammation
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
