NCT04942158 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Cappiello J
Pulp treatment in primary incisors [Spanish]. Rev Asoc Odontol Argent. 1964; 52(4): 139-145.
Coll JA, Dhar V, Vargas K, Chen CY, Crystal YO, AlShamali S, Marghalani AA
Use of Non-Vital Pulp Therapies in Primary Teeth. Pediatr Dent. 2020 Sep 15;42(5):337-349.
de Deus Moura Lde F, de Lima Mde D, Lima CC, Machado JI, de Moura MS, de Carvalho PV
Endodontic Treatment of Primary Molars with Antibiotic Paste: A Report of 38 Cases. J Clin Pediatr Dent. 2016;40(3):175-7. doi: 10.17796/1053-4628-40.3.175.
Duarte ML, Pires PM, Ferreira DM, Pintor AVB, de Almeida Neves A, Maia LC, Primo LG
Is there evidence for the use of lesion sterilization and tissue repair therapy in the endodontic treatment of primary teeth? A systematic review and meta-analyses. Clin Oral Investig. 2020 Sep;24(9):2959-2972. doi: 10.1007/s00784-020-03415-0. Epub 2020 Jul 14.
Pezzini Soares J, Cardoso M, Bolan M
Demystifying behaviour and dental anxiety in schoolchildren during endodontic treatment for primary teeth-controlled clinical trial. Int J Paediatr Dent. 2019 May;29(3):249-256. doi: 10.1111/ipd.12468. Epub 2019 Feb 1.

Efficacy of Non-instrumentation Endodontic Treatment With an Antibiotic Mix Paste in Primary Molars: a Multicenter Randomized Clinical Trial With 2 Years of Follow-up

Details for clinical trial NCT04942158

Clinical trial NCT04942158 - References