NCT04955860 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

da Silva Filho OG, Ferrari Júnior FM, Okada Ozawa T
Dental arch dimensions in Class II division 1 malocclusions with mandibular deficiency. Angle Orthod. 2008 May;78(3):466-74. doi: 10.2319/022307-89.1.
McNamara JA Jr, Baccetti T, Franchi L, Herberger TA
Rapid maxillary expansion followed by fixed appliances: a long-term evaluation of changes in arch dimensions. Angle Orthod. 2003 Aug;73(4):344-53.
McNamara JA Jr
Early intervention in the transverse dimension: is it worth the effort? Am J Orthod Dentofacial Orthop. 2002 Jun;121(6):572-4.

Evaluation of First Molar Inclinations and Dental Arch Parameters in Individuals With Bilateral Posterior Crossbite at Different Age Periods

Clinical trial NCT04955860 - References