NCT05409625 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Bellini HT, Arneberg P, von der Fehr FR
Oral hygiene and caries. A review. Acta Odontol Scand. 1981;39(5):257-65. Review.
de Josselin de Jong E, Sundström F, Westerling H, Tranaeus S, ten Bosch JJ, Angmar-Månsson B
A new method for in vivo quantification of changes in initial enamel caries with laser fluorescence. Caries Res. 1995;29(1):2-7.
Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W
Global burden of untreated caries: a systematic review and metaregression. J Dent Res. 2015 May;94(5):650-8. doi: 10.1177/0022034515573272. Epub 2015 Mar 4. Review.
LOE H, SILNESS J
PERIODONTAL DISEASE IN PREGNANCY. I. PREVALENCE AND SEVERITY. Acta Odontol Scand. 1963 Dec;21:533-51.
Lussi A, Hibst R, Paulus R
DIAGNOdent: an optical method for caries detection. J Dent Res. 2004;83 Spec No C:C80-3. Review.
Michou S, Benetti AR, Vannahme C, Hermannsson PG, Bakhshandeh A, Ekstrand KR
Development of a Fluorescence-Based Caries Scoring System for an Intraoral Scanner: An in vitro Study. Caries Res. 2020;54(4):324-335. doi: 10.1159/000509925. Epub 2020 Oct 14.
Pitts NB, Zero DT, Marsh PD, Ekstrand K, Weintraub JA, Ramos-Gomez F, Tagami J, Twetman S, Tsakos G, Ismail A
Dental caries. Nat Rev Dis Primers. 2017 May 25;3:17030. doi: 10.1038/nrdp.2017.30. Review.

3D Scanning and Transillumination vs Conventional Examination to Assess Caries Progression, Stability or Regression

Clinical trial NCT05409625 - References