Cole MG, McCusker J Treatment of delirium in older medical inpatients: a challenge for geriatric specialists. J Am Geriatr Soc. 2002 Dec;50(12):2101-3.
Fick DM, Agostini JV, Inouye SK Delirium superimposed on dementia: a systematic review. J Am Geriatr Soc. 2002 Oct;50(10):1723-32. Review.
Gentric A, Le Deun P, Estivin S [Prevention of delirium in an acute geriatric care unit]. Rev Med Interne. 2007 Sep;28(9):589-93. Epub 2007 May 15. French.
Hshieh TT, Yue J, Oh E, Puelle M, Dowal S, Travison T, Inouye SK Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis. JAMA Intern Med. 2015 Apr;175(4):512-20. doi: 10.1001/jamainternmed.2014.7779. Erratum in: JAMA Intern Med. 2015 Apr;175(4):659.
Martinez F, Tobar C, Hill N Preventing delirium: should non-pharmacological, multicomponent interventions be used? A systematic review and meta-analysis of the literature. Age Ageing. 2015 Mar;44(2):196-204. doi: 10.1093/ageing/afu173. Epub 2014 Nov 25. Review.
McCusker J, Cole MG, Dendukuri N, Belzile E The delirium index, a measure of the severity of delirium: new findings on reliability, validity, and responsiveness. J Am Geriatr Soc. 2004 Oct;52(10):1744-9.
Reston JT, Schoelles KM In-facility delirium prevention programs as a patient safety strategy: a systematic review. Ann Intern Med. 2013 Mar 5;158(5 Pt 2):375-80. doi: 10.7326/0003-4819-158-5-201303051-00003. Review.
Rockwood K Making delirium prevention acceptable in nursing homes. J Am Med Dir Assoc. 2014 Jan;15(1):6-7. doi: 10.1016/j.jamda.2013.09.002. Epub 2013 Oct 8.
Vidán MT, Sánchez E, Alonso M, Montero B, Ortiz J, Serra JA An intervention integrated into daily clinical practice reduces the incidence of delirium during hospitalization in elderly patients. J Am Geriatr Soc. 2009 Nov;57(11):2029-36. doi: 10.1111/j.1532-5415.2009.02485.x. Epub 2009 Sep 15.
Voyer P, Richard S, Doucet L, Carmichael PH Detecting delirium and subsyndromal delirium using different diagnostic criteria among demented long-term care residents. J Am Med Dir Assoc. 2009 Mar;10(3):181-8. doi: 10.1016/j.jamda.2008.09.006. Epub 2009 Jan 8.
Wei LA, Fearing MA, Sternberg EJ, Inouye SK The Confusion Assessment Method: a systematic review of current usage. J Am Geriatr Soc. 2008 May;56(5):823-30. doi: 10.1111/j.1532-5415.2008.01674.x. Epub 2008 Apr 1. Review.
The Prevention Program for Alzheimer's Related Delirium (PREPARED) Cluster Randomized Trial
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
