Dementia — Digital Phenotyping for Changes in Activity at the End of Life in People With Dementia
Citation(s)
Abbott KM, Bangerter LR, Humes S, Klumpp R, Van Haitsma K "It's important, but...": Perceived Barriers and Situational Dependencies to Social Contact Preferences of Nursing Home Residents. Gerontologist. 2018 Nov 3;58(6):1126-1135. doi: 10.1093/geront/gnx109.
Evensen S, Hylen Ranhoff A, Lydersen S, Saltvedt I The delirium screening tool 4AT in routine clinical practice: prediction of mortality, sensitivity and specificity. Eur Geriatr Med. 2021 Aug;12(4):793-800. doi: 10.1007/s41999-021-00489-1. Epub 2021 Apr 4.
Faeo SE, Husebo BS, Bruvik FK, Tranvag O "We live as good a life as we can, in the situation we're in" - the significance of the home as perceived by persons with dementia. BMC Geriatr. 2019 Jun 6;19(1):158. doi: 10.1186/s12877-019-1171-6.
Hui D, Bruera E The Edmonton Symptom Assessment System 25 Years Later: Past, Present, and Future Developments. J Pain Symptom Manage. 2017 Mar;53(3):630-643. doi: 10.1016/j.jpainsymman.2016.10.370. Epub 2016 Dec 29.
Husebo BS, Heintz HL, Berge LI, Owoyemi P, Rahman AT, Vahia IV Sensing Technology to Monitor Behavioral and Psychological Symptoms and to Assess Treatment Response in People With Dementia. A Systematic Review. Front Pharmacol. 2020 Feb 4;10:1699. doi: 10.3389/fphar.2019.01699. eCollection 2019. Erratum In: Front Pharmacol. 2020 Mar 06;11:254.
Husebo BS, Ostelo R, Strand LI The MOBID-2 pain scale: reliability and responsiveness to pain in patients with dementia. Eur J Pain. 2014 Nov;18(10):1419-30. doi: 10.1002/ejp.507. Epub 2014 May 5.
Johansen RH, Olsen K, Bergh S, Benth JS, Selbaek G, Helvik AS Course of activities of daily living in nursing home residents with dementia from admission to 36-month follow-up. BMC Geriatr. 2020 Nov 20;20(1):488. doi: 10.1186/s12877-020-01877-1.
Jorm AF The Informant Questionnaire on cognitive decline in the elderly (IQCODE): a review. Int Psychogeriatr. 2004 Sep;16(3):275-93. doi: 10.1017/s1041610204000390.
Park C, Mishra R, Golledge J, Najafi B Digital Biomarkers of Physical Frailty and Frailty Phenotypes Using Sensor-Based Physical Activity and Machine Learning. Sensors (Basel). 2021 Aug 5;21(16):5289. doi: 10.3390/s21165289.
Sandvik RK, Selbaek G, Bergh S, Aarsland D, Husebo BS Signs of Imminent Dying and Change in Symptom Intensity During Pharmacological Treatment in Dying Nursing Home Patients: A Prospective Trajectory Study. J Am Med Dir Assoc. 2016 Sep 1;17(9):821-7. doi: 10.1016/j.jamda.2016.05.006. Epub 2016 Jun 16.
Selbaek G, Kirkevold O, Sommer OH, Engedal K The reliability and validity of the Norwegian version of the Neuropsychiatric Inventory, nursing home version (NPI-NH). Int Psychogeriatr. 2008 Apr;20(2):375-82. doi: 10.1017/S1041610207005601. Epub 2007 Jun 11.
Vahia IV, Forester BP Motion mapping in humans as a biomarker for psychiatric disorders. Neuropsychopharmacology. 2019 Jan;44(1):231-232. doi: 10.1038/s41386-018-0205-7. No abstract available.
Vik-Mo AO, Giil LM, Borda MG, Ballard C, Aarsland D The individual course of neuropsychiatric symptoms in people with Alzheimer's and Lewy body dementia: 12-year longitudinal cohort study. Br J Psychiatry. 2020 Jan;216(1):43-48. doi: 10.1192/bjp.2019.195.
Digital Phenotyping for Changes in Activity at the End of Life in People With Dementia: an Observational Trial Based on Sensing Technology
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.