Diaz-Rossello JL A difficult ethics issue. Lancet. 2004 Nov 13-19;364(9447):1751-2; author reply 1752.
Fonseca D Importancia del aporte de sangre placentaria al niño recién nacido. Su medida por medio del registro ponderal continuo.Arch. Pediatr.Uruguay 1962; 7: 444.
Hutton EK, Hassan ES Late vs early clamping of the umbilical cord in full-term neonates: systematic review and meta-analysis of controlled trials. JAMA. 2007 Mar 21;297(11):1241-52. Review.
Lind J Physiological adaptation to the placental transfusion: the eleventh blackader lecture. Can Med Assoc J. 1965 Nov 20;93(21):1091-100.
McDonald SJ, Middleton P Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD004074. doi: 10.1002/14651858.CD004074.pub2. Review. Update in: Cochrane Database Syst Rev. 2013;7:CD004074.
Moore ER, Anderson GC, Bergman N Early skin-to-skin contact for mothers and their healthy newborn infants. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD003519. Review. Update in: Cochrane Database Syst Rev. 2012;5:CD003519.
Rabe H, Reynolds G, Diaz-Rossello J A systematic review and meta-analysis of a brief delay in clamping the umbilical cord of preterm infants. Neonatology. 2008;93(2):138-44. Epub 2007 Sep 21. Review.
van Rheenen PF, Brabin BJ Effect of timing of cord clamping on neonatal venous hematocrit values and clinical outcome at term: a randomized, controlled trial. Pediatrics. 2006 Sep;118(3):1317-8; author reply 1318-9.
Yao AC, Hirvensalo M, Lind J Placental transfusion-rate and uterine contraction. Lancet. 1968 Feb 24;1(7539):380-3.
Yao AC, Lind J Placental transfusion. Am J Dis Child. 1974 Jan;127(1):128-41. Review.
Yao AC, Moinian M, Lind J Distribution of blood between infant and placenta after birth. Lancet. 1969 Oct 25;2(7626):871-3.
Is the Placental Transfusion Volume Influenced by the Position of the New Born at Birth? a Pilot Study
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
