Clinical trial NCT04869579 - References

Covid19 — Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.

Citation(s)

•   Ahrens I, Ellwanger C, Smith BK, Bassler N, Chen YC, Neudorfer I, Ludwig A, Bode C, Peter K
  Selenium supplementation induces metalloproteinase-dependent L-selectin shedding from monocytes. J Leukoc Biol. 2008 Jun;83(6):1388-95. doi: 10.1189/jlb.0707497. Epub 2008 Feb 27.
•   Allingstrup M, Afshari A
  Selenium supplementation for critically ill adults. Cochrane Database Syst Rev. 2015 Jul 27;(7):CD003703. doi: 10.1002/14651858.CD003703.pub3. Review.
•   Amini P, Kolivand S, Saffar H, Rezapoor S, Motevaseli E, Najafi M, Nouruzi F, Shabeeb D, Musa AE
  Protective Effect of Selenium-L-methionine on Radiation-induced Acute Pneumonitis and Lung Fibrosis in Rat. Curr Clin Pharmacol. 2019;14(2):157-164. doi: 10.2174/1574884714666181214101917.
•   Angstwurm MW, Engelmann L, Zimmermann T, Lehmann C, Spes CH, Abel P, Strauss R, Meier-Hellmann A, Insel R, Radke J, Schüttler J, Gärtner R
  Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med. 2007 Jan;35(1):118-26.
•   Angstwurm MW, Gaertner R
  Practicalities of selenium supplementation in critically ill patients. Curr Opin Clin Nutr Metab Care. 2006 May;9(3):233-8. Review.
•   Avery JC, Hoffmann PR
  Selenium, Selenoproteins, and Immunity. Nutrients. 2018 Sep 1;10(9). pii: E1203. doi: 10.3390/nu10091203. Review.
•   Bargagli E, Olivieri C, Bennett D, Prasse A, Muller-Quernheim J, Rottoli P
  Oxidative stress in the pathogenesis of diffuse lung diseases: a review. Respir Med. 2009 Sep;103(9):1245-56. doi: 10.1016/j.rmed.2009.04.014. Epub 2009 May 22. Review.
•   Beck MA, Levander OA, Handy J
  Selenium deficiency and viral infection. J Nutr. 2003 May;133(5 Suppl 1):1463S-7S. doi: 10.1093/jn/133.5.1463S. Review.
•   Beck MA
  Antioxidants and viral infections: host immune response and viral pathogenicity. J Am Coll Nutr. 2001 Oct;20(5 Suppl):384S-388S; discussion 396S-397S. Review.
•   Beck MA
  Selenium and host defence towards viruses. Proc Nutr Soc. 1999 Aug;58(3):707-11. Review.
•   Chu VC, McElroy LJ, Chu V, Bauman BE, Whittaker GR
  The avian coronavirus infectious bronchitis virus undergoes direct low-pH-dependent fusion activation during entry into host cells. J Virol. 2006 Apr;80(7):3180-8.
•   Conti P, Ronconi G, Caraffa A, Gallenga CE, Ross R, Frydas I, Kritas SK
  Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020 March-April,;34(2):327-331. doi: 10.23812/CONTI-E.
•   Fontaine M, Valli VE, Young LG
  Studies on vitamin E and selenium deficiency in young pigs. IV. Effect on coagulation system. Can J Comp Med. 1977 Jan;41(1):64-76.
•   Gazi MH, Gong A, Donkena KV, Young CY
  Sodium selenite inhibits interleukin-6-mediated androgen receptor activation in prostate cancer cells via upregulation of c-Jun. Clin Chim Acta. 2007 May 1;380(1-2):145-50. Epub 2007 Feb 11.
•   Ghosh P, Bhattacharjee A, Basu A, Singha Roy S, Bhattacharya S
  Attenuation of cyclophosphamide-induced pulmonary toxicity in Swiss albino mice by naphthalimide-based organoselenium compound 2-(5-selenocyanatopentyl)-benzo[de]isoquinoline 1,3-dione. Pharm Biol. 2015 Apr;53(4):524-32. doi: 10.3109/13880209.2014.931440. Epub 2014 Dec 4.
•   Hardy G, Hardy I, Manzanares W
  Selenium supplementation in the critically ill. Nutr Clin Pract. 2012 Feb;27(1):21-33. doi: 10.1177/0884533611434116. Review.
•   Hassanzadeh M, Faridhosseini R, Mahini M, Faridhosseini F, Ranjbar A
  Serum Levels of TNF-, IL-6, and Selenium in Patients with Acute and Chronic Coronary Artery Disease. Iran J Immunol. 2006 Sep;3(3):142-5. doi: IJIv3i3A7.
•   Heyland DK, Dhaliwal R, Suchner U, Berger MM
  Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med. 2005 Mar;31(3):327-37. Epub 2004 Dec 17. Review.
•   Hoffmann PR, Berry MJ
  The influence of selenium on immune responses. Mol Nutr Food Res. 2008 Nov;52(11):1273-80. doi: 10.1002/mnfr.200700330. Review.
•   Hori K, Hatfield D, Maldarelli F, Lee BJ, Clouse KA
  Selenium supplementation suppresses tumor necrosis factor alpha-induced human immunodeficiency virus type 1 replication in vitro. AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1325-32.
•   Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B
  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24. Erratum in: Lancet. 2020 Jan 30;:.
•   Jaspers I, Zhang W, Brighton LE, Carson JL, Styblo M, Beck MA
  Selenium deficiency alters epithelial cell morphology and responses to influenza. Free Radic Biol Med. 2007 Jun 15;42(12):1826-37. Epub 2007 Mar 24.
•   Kellner M, Noonepalle S, Lu Q, Srivastava A, Zemskov E, Black SM
  ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). Adv Exp Med Biol. 2017;967:105-137. doi: 10.1007/978-3-319-63245-2_8.
•   Kempf T, Wollert KC
  Risk stratification in critically ill patients: GDF-15 scores in adult respiratory distress syndrome. Crit Care. 2013 Jul 31;17(4):173. doi: 10.1186/cc12765.
•   Kim KS, Suh GJ, Kwon WY, Kwak YH, Lee K, Lee HJ, Jeong KY, Lee MW
  Antioxidant effects of selenium on lung injury in paraquat intoxicated rats. Clin Toxicol (Phila). 2012 Sep;50(8):749-53. doi: 10.3109/15563650.2012.708418.
•   Liu J, Yang Y, Zeng X, Bo L, Jiang S, Du X, Xie Y, Jiang R, Zhao J, Song W
  Investigation of selenium pretreatment in the attenuation of lung injury in rats induced by fine particulate matters. Environ Sci Pollut Res Int. 2017 Feb;24(4):4008-4017. doi: 10.1007/s11356-016-8173-0. Epub 2016 Dec 5.
•   Ma X, Bi S, Wang Y, Chi X, Hu S
  Combined adjuvant effect of ginseng stem-leaf saponins and selenium on immune responses to a live bivalent vaccine of Newcastle disease virus and infectious bronchitis virus in chickens. Poult Sci. 2019 Sep 1;98(9):3548-3556. doi: 10.3382/ps/pez207.
•   Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O
  Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol. 2020 Jul 1;5(7):831-840. doi: 10.1001/jamacardio.2020.1286. Review.
•   Manzanares W, Biestro A, Galusso F, Torre MH, Mañáy N, Facchin G, Hardy G
  High-dose selenium for critically ill patients with systemic inflammation: pharmacokinetics and pharmacodynamics of selenious acid: a pilot study. Nutrition. 2010 Jun;26(6):634-40. doi: 10.1016/j.nut.2009.06.022. Epub 2010 Jan 15.
•   Manzanares W, Langlois PL, Heyland DK
  Pharmaconutrition with selenium in critically ill patients: what do we know? Nutr Clin Pract. 2015 Feb;30(1):34-43. doi: 10.1177/0884533614561794. Epub 2014 Dec 18. Review.
•   Marty AM, Jones MK
  The novel Coronavirus (SARS-CoV-2) is a one health issue. One Health. 2020 Feb 14;9:100123. doi: 10.1016/j.onehlt.2020.100123. eCollection 2020 Jun.
•   Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ; HLH Across Speciality Collaboration, UK
  COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020 Mar 28;395(10229):1033-1034. doi: 10.1016/S0140-6736(20)30628-0. Epub 2020 Mar 16.
•   Nuttall KL
  Evaluating selenium poisoning. Ann Clin Lab Sci. 2006 Autumn;36(4):409-20. Review.
•   Perona G, Schiavon R, Guidi GC, Veneri D, Minuz P
  Selenium dependent glutathione peroxidase: a physiological regulatory system for platelet function. Thromb Haemost. 1990 Oct 22;64(2):312-8.
•   Ricetti MM, Guidi GC, Bellisola G, Marrocchella R, Rigo A, Perona G
  Selenium enhances glutathione peroxidase activity and prostacyclin release in cultured human endothelial cells. Concurrent effects on mRNA levels. Biol Trace Elem Res. 1994 Oct-Nov;46(1-2):113-23.
•   Rojo de la Vega M, Dodson M, Gross C, Mansour HM, Lantz RC, Chapman E, Wang T, Black SM, Garcia JG, Zhang DD
  Role of Nrf2 and Autophagy in Acute Lung Injury. Curr Pharmacol Rep. 2016 Apr;2(2):91-101. Epub 2016 Feb 6.
•   Ronco C, Reis T
  Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nat Rev Nephrol. 2020 Jun;16(6):308-310. doi: 10.1038/s41581-020-0284-7.
•   Ruan Q, Yang K, Wang W, Jiang L, Song J
  Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020 May;46(5):846-848. doi: 10.1007/s00134-020-05991-x. Epub 2020 Mar 3. Erratum in: Intensive Care Med. 2020 Apr 6;:.
•   Sakr Y, Reinhart K, Bloos F, Marx G, Russwurm S, Bauer M, Brunkhorst F
  Time course and relationship between plasma selenium concentrations, systemic inflammatory response, sepsis, and multiorgan failure. Br J Anaesth. 2007 Jun;98(6):775-84. Epub 2007 May 3.
•   Schmidt T, Pargger H, Seeberger E, Eckhart F, von Felten S, Haberthür C
  Effect of high-dose sodium selenite in cardiac surgery patients: A randomized controlled bi-center trial. Clin Nutr. 2018 Aug;37(4):1172-1180. doi: 10.1016/j.clnu.2017.04.019. Epub 2017 May 2.
•   Schrauzer GN, Sacher J
  Selenium in the maintenance and therapy of HIV-infected patients. Chem Biol Interact. 1994 Jun;91(2-3):199-205. Review. Erratum in: Chem Biol Interact 1995 Feb;94(2):167.
•   Steinbrenner H, Al-Quraishy S, Dkhil MA, Wunderlich F, Sies H
  Dietary selenium in adjuvant therapy of viral and bacterial infections. Adv Nutr. 2015 Jan 15;6(1):73-82. doi: 10.3945/an.114.007575. Print 2015 Jan. Review.
•   Steinbrenner H, Sies H
  Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta. 2009 Nov;1790(11):1478-85. doi: 10.1016/j.bbagen.2009.02.014. Epub 2009 Mar 5. Review.
•   Steinbrenner H, Speckmann B, Klotz LO
  Selenoproteins: Antioxidant selenoenzymes and beyond. Arch Biochem Biophys. 2016 Apr 1;595:113-9. doi: 10.1016/j.abb.2015.06.024. Review.
•   Tindell R, Wall SB, Li Q, Li R, Dunigan K, Wood R, Tipple TE
  Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition. Redox Biol. 2018 Oct;19:331-338. doi: 10.1016/j.redox.2018.07.020. Epub 2018 Sep 5. Erratum in: Redox Biol. 2020 Jan;28:100992.
•   Vaninov N
  In the eye of the COVID-19 cytokine storm. Nat Rev Immunol. 2020 May;20(5):277. doi: 10.1038/s41577-020-0305-6.
•   Wang JZ, Zhang RY, Bai J
  An anti-oxidative therapy for ameliorating cardiac injuries of critically ill COVID-19-infected patients. Int J Cardiol. 2020 Aug 1;312:137-138. doi: 10.1016/j.ijcard.2020.04.009. Epub 2020 Apr 6.
•   Weiss SR, Navas-Martin S
  Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev. 2005 Dec;69(4):635-64. Review.
•   Wu C, Liu Y, Yang Y, Zhang P, Zhong W, Wang Y, Wang Q, Xu Y, Li M, Li X, Zheng M, Chen L, Li H
  Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods. Acta Pharm Sin B. 2020 May;10(5):766-788. doi: 10.1016/j.apsb.2020.02.008. Epub 2020 Feb 27.
•   Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, Tai Y, Bai C, Gao T, Song J, Xia P, Dong J, Zhao J, Wang FS
  Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020 Apr;8(4):420-422. doi: 10.1016/S2213-2600(20)30076-X. Epub 2020 Feb 18. Erratum in: Lancet Respir Med. 2020 Feb 25;:.
•   Zhang C, Lin J, Ge J, Wang LL, Li N, Sun XT, Cao HB, Li JL
  Selenium triggers Nrf2-mediated protection against cadmium-induced chicken hepatocyte autophagy and apoptosis. Toxicol In Vitro. 2017 Oct;44:349-356. doi: 10.1016/j.tiv.2017.07.027. Epub 2017 Jul 29.
•   Zhang C, Wu Z, Li JW, Zhao H, Wang GQ
  Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality. Int J Antimicrob Agents. 2020 May;55(5):105954. doi: 10.1016/j.ijantimicag.2020.105954. Epub 2020 Mar 29.
•   Zhang J, Taylor EW, Bennett K, Saad R, Rayman MP
  Association between regional selenium status and reported outcome of COVID-19 cases in China. Am J Clin Nutr. 2020 Jun 1;111(6):1297-1299. doi: 10.1093/ajcn/nqaa095.
•   Zhang Y, Jiang M, Nouraie M, Roth MG, Tabib T, Winters S, Chen X, Sembrat J, Chu Y, Cardenes N, Tuder RM, Herzog EL, Ryu C, Rojas M, Lafyatis R, Gibson KF, McDyer JF, Kass DJ, Alder JK
  GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2019 Oct 1;317(4):L510-L521. doi: 10.1152/ajplung.00062.2019. Epub 2019 Aug 21.
•   Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, Chen H, Ding X, Zhao H, Zhang H, Wang C, Zhao J, Sun X, Tian R, Wu W, Wu D, Ma J, Chen Y, Zhang D, Xie J, Yan X, Zhou X, Liu Z, Wang J, Du B, Qin Y, Gao P, Qin X, Xu Y, Zhang W, Li T, Zhang F, Zhao Y, Li Y, Zhang S
  Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Engl J Med. 2020 Apr 23;382(17):e38. doi: 10.1056/NEJMc2007575. Epub 2020 Apr 8.
•   Zhao Y, Yang M, Mao Z, Yuan R, Wang L, Hu X, Zhou F, Kang H
  The clinical outcomes of selenium supplementation on critically ill patients: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2019 May;98(20):e15473. doi: 10.1097/MD.0000000000015473.
•   Zheng YY, Ma YT, Zhang JY, Xie X
  COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020 May;17(5):259-260. doi: 10.1038/s41569-020-0360-5.
•   Zhou X, Wang Z, Chen J, Wang W, Song D, Li S, Yang H, Xue S, Chen C
  Increased levels of IL-6, IL-1ß, and TNF-a in Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency. Rheumatol Int. 2014 Jul;34(7):995-1004. doi: 10.1007/s00296-013-2862-5. Epub 2013 Sep 15.

Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients

Details for clinical trial NCT04869579