COVID-19 — Neuromodulation With Percutaneous Electrical Nerve Field Stimulation for Adults With COVID-19
Citation(s)
Babygirija R, Sood M, Kannampalli P, Sengupta JN, Miranda A Percutaneous electrical nerve field stimulation modulates central pain pathways and attenuates post-inflammatory visceral and somatic hyperalgesia in rats. Neuroscience. 2017 Jul 25;356:11-21. doi: 10.1016/j.neuroscience.2017.05.012. Epub 2017 May 17.
Berthoud HR, Neuhuber WL Functional and chemical anatomy of the afferent vagal system. Auton Neurosci. 2000 Dec 20;85(1-3):1-17. doi: 10.1016/S1566-0702(00)00215-0.
dos Santos CC, Shan Y, Akram A, Slutsky AS, Haitsma JJ Neuroimmune regulation of ventilator-induced lung injury. Am J Respir Crit Care Med. 2011 Feb 15;183(4):471-82. doi: 10.1164/rccm.201002-0314OC. Epub 2010 Sep 24.
Hertweck MS, Hung KS Ultrastructural evidence for the innervation of human pulmonary alveoli. Experientia. 1980 Jan 15;36(1):112-3. doi: 10.1007/BF02004006.
Johnson RL, Wilson CG A review of vagus nerve stimulation as a therapeutic intervention. J Inflamm Res. 2018 May 16;11:203-213. doi: 10.2147/JIR.S163248. eCollection 2018.
Miranda A, Taca A Neuromodulation with percutaneous electrical nerve field stimulation is associated with reduction in signs and symptoms of opioid withdrawal: a multisite, retrospective assessment. Am J Drug Alcohol Abuse. 2018;44(1):56-63. doi: 10.1080/00952990.2017.1295459. Epub 2017 Mar 16. Erratum In: Am J Drug Alcohol Abuse. 2018;44(4):498.
Pawelec G, Adibzadeh M, Pohla H, Schaudt K Immunosenescence: ageing of the immune system. Immunol Today. 1995 Sep;16(9):420-2. doi: 10.1016/0167-5699(95)80017-4. No abstract available.
Peuker ET, Filler TJ The nerve supply of the human auricle. Clin Anat. 2002 Jan;15(1):35-7. doi: 10.1002/ca.1089.
Roberts A, Sithole A, Sedghi M, Walker CA, Quinn TM Minimal adverse effects profile following implantation of periauricular percutaneous electrical nerve field stimulators: a retrospective cohort study. Med Devices (Auckl). 2016 Nov 3;9:389-393. doi: 10.2147/MDER.S107426. eCollection 2016.
Russell B, Moss C, Rigg A, Hopkins C, Papa S, Van Hemelrijck M Anosmia and ageusia are emerging as symptoms in patients with COVID-19: What does the current evidence say? Ecancermedicalscience. 2020 Apr 3;14:ed98. doi: 10.3332/ecancer.2020.ed98. eCollection 2020.
Sun P, Zhou K, Wang S, Li P, Chen S, Lin G, Zhao Y, Wang T Involvement of MAPK/NF-kappaB signaling in the activation of the cholinergic anti-inflammatory pathway in experimental colitis by chronic vagus nerve stimulation. PLoS One. 2013 Aug 2;8(8):e69424. doi: 10.1371/journal.pone.0069424. Print 2013.
Tracey KJ Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest. 2007 Feb;117(2):289-96. doi: 10.1172/JCI30555.
Vaira LA, Salzano G, Deiana G, De Riu G Anosmia and Ageusia: Common Findings in COVID-19 Patients. Laryngoscope. 2020 Jul;130(7):1787. doi: 10.1002/lary.28692. Epub 2020 Apr 15.
Wu H, Li L, Su X Vagus nerve through alpha7 nAChR modulates lung infection and inflammation: models, cells, and signals. Biomed Res Int. 2014;2014:283525. doi: 10.1155/2014/283525. Epub 2014 Jul 20.
Wu Z, McGoogan JM Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020 Apr 7;323(13):1239-1242. doi: 10.1001/jama.2020.2648. No abstract available.
Yang X, Zhao C, Gao Z, Su X A novel regulator of lung inflammation and immunity: pulmonary parasympathetic inflammatory reflex. QJM. 2014 Oct;107(10):789-92. doi: 10.1093/qjmed/hcu005. Epub 2014 Jan 18.
Zhao YX, He W, Jing XH, Liu JL, Rong PJ, Ben H, Liu K, Zhu B Transcutaneous auricular vagus nerve stimulation protects endotoxemic rat from lipopolysaccharide-induced inflammation. Evid Based Complement Alternat Med. 2012;2012:627023. doi: 10.1155/2012/627023. Epub 2012 Dec 29.
Neuromodulation With Percutaneous Electrical Nerve Field Stimulation for Adults With COVID-19
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.