COVID-19 — Complementary Intervention for COVID-19
Citation(s)
Ammon HP Boswellic Acids and Their Role in Chronic Inflammatory Diseases. Adv Exp Med Biol. 2016;928:291-327. Review.
Ammon HP Modulation of the immune system by Boswellia serrata extracts and boswellic acids. Phytomedicine. 2010 Sep;17(11):862-7. doi: 10.1016/j.phymed.2010.03.003. Epub 2010 Aug 8. Review. Erratum in: Phytomedicine. 2011 Feb 15;18(4):334.
Guo A, He D, Xu HB, Geng CA, Zhao J Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents. Sci Rep. 2015 Sep 15;5:14046. doi: 10.1038/srep14046.
Kong D, Wang Z, Tian J, Liu T, Zhou H Glycyrrhizin inactivates toll-like receptor (TLR) signaling pathway to reduce lipopolysaccharide-induced acute lung injury by inhibiting TLR2. J Cell Physiol. 2019 Apr;234(4):4597-4607. doi: 10.1002/jcp.27242. Epub 2018 Sep 10.
Luo P, Liu D, Li J Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19. Int J Antimicrob Agents. 2020 Jun;55(6):105995. doi: 10.1016/j.ijantimicag.2020.105995. Epub 2020 Apr 24.
Soni KK, Meshram D, Lawal TO, Patel U, Mahady GB Fractions of Boswellia Serrata Suppress LTA(4), LTC(4), Cyclooxygenase-2 Activities and mRNA in HL-60 Cells and Reduce Lung Inflammation in BALB/c Mice. Curr Drug Discov Technol. 2021;18(1):95-104. doi: 10.2174/1570163817666200127112928.
Sun ZG, Zhao TT, Lu N, Yang YA, Zhu HL Research Progress of Glycyrrhizic Acid on Antiviral Activity. Mini Rev Med Chem. 2019;19(10):826-832. doi: 10.2174/1389557519666190119111125. Review.
Wang L, Yang R, Yuan B, Liu Y, Liu C The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta Pharm Sin B. 2015 Jul;5(4):310-5. doi: 10.1016/j.apsb.2015.05.005. Epub 2015 Jun 17. Review.
Yu X, Bao Y, Meng X, Wang S, Li T, Chang X, Xu W, Yang G, Bo T Multi-pathway integrated adjustment mechanism of licorice flavonoids presenting anti-inflammatory activity. Oncol Lett. 2019 Nov;18(5):4956-4963. doi: 10.3892/ol.2019.10793. Epub 2019 Sep 4.
Zhou X, Cai JG, Zhu WW, Zhao HY, Wang K, Zhang XF Boswellic acid attenuates asthma phenotype by downregulation of GATA3 via nhibition of PSTAT6. Genet Mol Res. 2015 Jul 6;14(3):7463-8. doi: 10.4238/2015.July.3.22.
Evaluation of The Potential Therapeutic Effects of Licorice and Boswellia Serrata Gum in Egyptian Patients With COVID-19 as a Complementary Medicine
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.