COVID-19 — Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19
Citation(s)
Kingsley DH, Pérez-Pérez RE, Niemira BA, Fan X Evaluation of gaseous chlorine dioxide for the inactivation of Tulane virus on blueberries. Int J Food Microbiol. 2018 May 20;273:28-32. doi: 10.1016/j.ijfoodmicro.2018.01.024. Epub 2018 Feb 1.
Montazeri N, Manuel C, Moorman E, Khatiwada JR, Williams LL, Jaykus LA Virucidal Activity of Fogged Chlorine Dioxide- and Hydrogen Peroxide-Based Disinfectants against Human Norovirus and Its Surrogate, Feline Calicivirus, on Hard-to-Reach Surfaces. Front Microbiol. 2017 Jun 8;8:1031. doi: 10.3389/fmicb.2017.01031. eCollection 2017.
Schijven J, Teunis P, Suylen T, Ketelaars H, Hornstra L, Rutjes S QMRA of adenovirus in drinking water at a drinking water treatment plant using UV and chlorine dioxide disinfection. Water Res. 2019 Jul 1;158:34-45. doi: 10.1016/j.watres.2019.03.090. Epub 2019 Apr 1.
Zhu Z, Guo Y, Yu P, Wang X, Zhang X, Dong W, Liu X, Guo C Chlorine dioxide inhibits the replication of porcine reproductive and respiratory syndrome virus by blocking viral attachment. Infect Genet Evol. 2019 Jan;67:78-87. doi: 10.1016/j.meegid.2018.11.0
Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
