Clinical trial NCT04337918 - References

Corona Virus Infection — Nitric Oxide Releasing Solutions to Prevent and Treat Mild/Moderate COVID-19 Infection

Citation(s)

•   Colasanti M, Persichini T, Venturini G, Ascenzi P
  S-nitrosylation of viral proteins: molecular bases for antiviral effect of nitric oxide. IUBMB Life. 1999 Jul;48(1):25-31. Review.
•   Deppisch C, Herrmann G, Graepler-Mainka U, Wirtz H, Heyder S, Engel C, Marschal M, Miller CC, Riethmüller J
  Gaseous nitric oxide to treat antibiotic resistant bacterial and fungal lung infections in patients with cystic fibrosis: a phase I clinical study. Infection. 2016 Aug;44(4):513-20. doi: 10.1007/s15010-016-0879-x. Epub 2016 Feb 9.
•   McMullin BB, Chittock DR, Roscoe DL, Garcha H, Wang L, Miller CC
  The antimicrobial effect of nitric oxide on the bacteria that cause nosocomial pneumonia in mechanically ventilated patients in the intensive care unit. Respir Care. 2005 Nov;50(11):1451-6.
•   Miller C, Miller M, McMullin B, Regev G, Serghides L, Kain K, Road J, Av-Gay Y
  A phase I clinical study of inhaled nitric oxide in healthy adults. J Cyst Fibros. 2012 Jul;11(4):324-31. doi: 10.1016/j.jcf.2012.01.003. Epub 2012 Apr 18.
•   Miller CC, Hergott CA, Rohan M, Arsenault-Mehta K, Döring G, Mehta S
  Inhaled nitric oxide decreases the bacterial load in a rat model of Pseudomonas aeruginosa pneumonia. J Cyst Fibros. 2013 Dec;12(6):817-20. doi: 10.1016/j.jcf.2013.01.008. Epub 2013 Mar 6.
•   Regev-Shoshani G, McMullin B, Nation N, Church JS, Dorin C, Miller C
  Non-inferiority of nitric oxide releasing intranasal spray compared to sub-therapeutic antibiotics to reduce incidence of undifferentiated fever and bovine respiratory disease complex in low to moderate risk beef cattle arriving at a commercial feedlot. Prev Vet Med. 2017 Mar 1;138:162-169. doi: 10.1016/j.prevetmed.2015.04.008. Epub 2015 Apr 20.
•   Regev-Shoshani G, Vimalanathan S, McMullin B, Road J, Av-Gay Y, Miller C
  Gaseous nitric oxide reduces influenza infectivity in vitro. Nitric Oxide. 2013 May 31;31:48-53. doi: 10.1016/j.niox.2013.03.007. Epub 2013 Apr 2.
•   Reiss CS, Komatsu T
  Does nitric oxide play a critical role in viral infections? J Virol. 1998 Jun;72(6):4547-51. Review.

Multi-Center, Randomized, Controlled, Phase II Clinical Efficacy Study Evaluating Nitric Oxide Releasing Solution Treatment for the Prevention and Treatment of COVID-19 in Healthcare Workers and Individuals at Risk of Infection

Details for clinical trial NCT04337918