NCT03077152 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, Nelson NA
Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987 Feb;106(2):196-204.
Bronzwaer SL, Cars O, Buchholz U, Mölstad S, Goettsch W, Veldhuijzen IK, Kool JL, Sprenger MJ, Degener JE; European Antimicrobial Resistance Surveillance System
A European study on the relationship between antimicrobial use and antimicrobial resistance. Emerg Infect Dis. 2002 Mar;8(3):278-82.
Llor C, Bjerrum L, Munck A, Hansen MP, Córdoba GC, Strandberg EL, Ovhed I, Radzeviciene R, Cots JM, Reutskiy A, Caballero L
Predictors for antibiotic prescribing in patients with exacerbations of COPD in general practice. Ther Adv Respir Dis. 2013 Jun;7(3):131-7. doi: 10.1177/1753465812472387. Epub 2013 Jan 16.
Tobia CC, Aspinall SL, Good CB, Fine MJ, Hanlon JT
Appropriateness of antibiotic prescribing in veterans with community-acquired pneumonia, sinusitis, or acute exacerbations of chronic bronchitis: a cross-sectional study. Clin Ther. 2008 Jun;30(6):1135-44. doi: 10.1016/j.clinthera.2008.06.009.

Patient Factors Associated With Prescription of Antibiotics for Inappropriate Indication in Patients With AECOPD

Clinical trial NCT03077152 - References