Borg GA Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81.
Eaton T, Young P, Nicol K, Kolbe J The endurance shuttle walking test: a responsive measure in pulmonary rehabilitation for COPD patients. Chron Respir Dis. 2006;3(1):3-9.
Emery CF, Honn VJ, Frid DJ, Lebowitz KR, Diaz PT Acute effects of exercise on cognition in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001 Nov 1;164(9):1624-7.
Kozora E, Tran ZV, Make B Neurobehavioral improvement after brief rehabilitation in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil. 2002 Nov-Dec;22(6):426-30.
O'Donnell DE, Lam M, Webb KA Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1557-65.
Rizk AK, Wardini R, Chan-Thim E, Bacon SL, Lavoie KL, Pepin V Acute responses to exercise training and relationship with exercise adherence in moderate chronic obstructive pulmonary disease. Chron Respir Dis. 2015 Nov;12(4):329-39. doi: 10.1177/147997231
Solway S, Brooks D, Lacasse Y, Thomas S A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest. 2001 Jan;119(1):256-70. Review.
Strauss, E , E.M. Sherman, and O. Spreen, A compendium of neuropsychological tests: administration, norms, and commentary. 3rd ed. 2006, New-York, NY: Oxford University Press.
Ware, J E., et al., SF-36 Health Survey Manual and Interpretation Guide. 1993, Boston, MA: The Health Institute, New England Medical Center.
Ware, J E., M. Kosinski, and S.D. Keller, SF-36 Physical and Mental Health Summary Measures. 1994, Boston, MA: The Health Institute, New England Medical Center.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
