Complication of Hemodialysis — REmoval of Free Light Chains. A COmpaRison of Three Different dialyzERs
Citation(s)
Aoike I Clinical significance of protein adsorbable membranes--long-term clinical effects and analysis using a proteomic technique. Nephrol Dial Transplant. 2007 Jul;22 Suppl 5:v13-9. Review.
Bergström J, Wehle B No change in corrected beta 2-microglobulin concentration after cuprophane haemodialysis. Lancet. 1987 Mar 14;1(8533):628-9.
Lamy T, Henri P, Lobbedez T, Comby E, Ryckelynck JP, Ficheux M Comparison between on-line high-efficiency hemodiafiltration and conventional high-flux hemodialysis for polyclonal free light chain removal. Blood Purif. 2014;37(2):93-8. doi: 10.1159/000357968. Epub 2014 Mar 1.
Machiguchi T, Tamura T, Yoshida H Efficacy of haemodiafiltration treatment with PEPA dialysis membranes in plasma free light chain removal in a patient with primary amyloidosis. Nephrol Dial Transplant. 2002 Sep;17(9):1689-91.
Rousseau-Gagnon M, Agharazii M, De Serres SA, Desmeules S Effectiveness of Haemodiafiltration with Heat Sterilized High-Flux Polyphenylene HF Dialyzer in Reducing Free Light Chains in Patients with Myeloma Cast Nephropathy. PLoS One. 2015 Oct 14;10(10):e0140463. doi: 10.1371/journal.pone.0140463. eCollection 2015.
Santoro A, Grazia M, Mancini E The double polymethylmethacrylate filter (DELETE system) in the removal of light chains in chronic dialysis patients with multiple myeloma. Blood Purif. 2013;35 Suppl 2:5-13. doi: 10.1159/000350837. Epub 2013 May 3. Review.
Testa A, Dejoie T, Lecarrer D, Wratten M, Sereni L, Renaux JL Reduction of free immunoglobulin light chains using adsorption properties of hemodiafiltration with endogenous reinfusion. Blood Purif. 2010;30(1):34-6. doi: 10.1159/000316684. Epub 2010 Jun 24.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
