Breit GA, Gross JH, Watenpaugh DE, Chance B, Hargens AR Near-infrared spectroscopy for monitoring of tissue oxygenation of exercising skeletal muscle in a chronic compartment syndrome model. J Bone Joint Surg Am. 1997 Jun;79(6):838-43.
Cathcart CC, Shuler MS, Freedman BA, Reno LR, Budsberg SC Correlation of near-infrared spectroscopy and direct pressure monitoring in an acute porcine compartmental syndrome model. J Orthop Trauma. 2014 Jun;28(6):365-9. doi: 10.1097/BOT.0b013e3182a75ceb.
Clayton JM, Hayes AC, Barnes RW Tissue pressure and perfusion in the compartment syndrome. J Surg Res. 1977 Apr;22(4):333-9.
Feldman F, Nickoloff EL Normal thermographic standards for the cervical spine and upper extremities. Skeletal Radiol. 1984;12(4):235-49.
Garr JL, Gentilello LM, Cole PA, Mock CN, Matsen FA 3rd Monitoring for compartmental syndrome using near-infrared spectroscopy: a noninvasive, continuous, transcutaneous monitoring technique. J Trauma. 1999 Apr;46(4):613-6; discussion 617-8.
Gentilello LM, Sanzone A, Wang L, Liu PY, Robinson L Near-infrared spectroscopy versus compartment pressure for the diagnosis of lower extremity compartmental syndrome using electromyography-determined measurements of neuromuscular function. J Trauma. 20
Lima A, Bakker J Near-infrared spectroscopy for monitoring peripheral tissue perfusion in critically ill patients. Rev Bras Ter Intensiva. 2011 Sep;23(3):341-51. English, Portuguese.
Lin PH, Saines M Assessment of lower extremity ischemia using smartphone thermographic imaging. J Vasc Surg Cases Innov Tech. 2017 Oct 14;3(4):205-208. doi: 10.1016/j.jvscit.2016.10.012. eCollection 2017 Dec.
Lynch JE, Lynch JK, Cole SL, Carter JA, Hargens AR Noninvasive monitoring of elevated intramuscular pressure in a model compartment syndrome via quantitative fascial motion. J Orthop Res. 2009 Apr;27(4):489-94. doi: 10.1002/jor.20778.
Mc Loughlin S, Mc Loughlin MJ, Mateu F Pulsed Doppler in simulated compartment syndrome: a pilot study to record hemodynamic compromise. Ochsner J. 2013 Winter;13(4):500-6.
McQueen MM, Duckworth AD The diagnosis of acute compartment syndrome: a review. Eur J Trauma Emerg Surg. 2014 Oct;40(5):521-8. doi: 10.1007/s00068-014-0414-7. Epub 2014 Jun 3.
Mubarak SJ, Hargens AR Acute compartment syndromes. Surg Clin North Am. 1983 Jun;63(3):539-65. Review.
Olson SA, Glasgow RR Acute compartment syndrome in lower extremity musculoskeletal trauma. J Am Acad Orthop Surg. 2005 Nov;13(7):436-44. Review.
Rosales-Velderrain A, Padilla M, Choe CH, Hargens AR Increased microvascular flow and foot sensation with mild continuous external compression. Physiol Rep. 2013 Dec 19;1(7):e00157. doi: 10.1002/phy2.157. eCollection 2013 Dec 1.
Shadgan B, Pereira G, Menon M, Jafari S, Darlene Reid W, O'Brien PJ Risk factors for acute compartment syndrome of the leg associated with tibial diaphyseal fractures in adults. J Orthop Traumatol. 2015 Sep;16(3):185-92. doi: 10.1007/s10195-014-0330-y. Epub 2014 Dec 28.
Thangam S, Vaz M, Kurpad AV, Shetty PS Superficial thermal gradients during mild body cooling and its relationship to forearm blood flow. Indian J Physiol Pharmacol. 1993 Oct;37(4):328-32.
Theuma F, Cassar K The use of smartphone-attached thermography camera in diagnosis of acute lower limb ischemia. J Vasc Surg. 2018 Apr;67(4):1297. doi: 10.1016/j.jvs.2017.02.054.
Turnipseed WD, Hurschler C, Vanderby R Jr The effects of elevated compartment pressure on tibial arteriovenous flow and relationship of mechanical and biochemical characteristics of fascia to genesis of chronic anterior compartment syndrome. J Vasc Surg.
von Keudell AG, Weaver MJ, Appleton PT, Bae DS, Dyer GSM, Heng M, Jupiter JB, Vrahas MS Diagnosis and treatment of acute extremity compartment syndrome. Lancet. 2015 Sep 26;386(10000):1299-1310. doi: 10.1016/S0140-6736(15)00277-9. Review. Erratum in: Lancet. 2015 Nov 7;386(10006):1824. Appelton, Paul T [corrected to Appleton, Paul T]. Lancet. 2015 Nov 7;386(10006):1824.
Wiebe S, Kellenberger CJ, Khoury A, Miller SF Early Doppler changes in a renal transplant patient secondary to abdominal compartment syndrome. Pediatr Radiol. 2004 May;34(5):432-4. Epub 2003 Dec 17.
The Value of Multimodal Monitoring in the Treatment of Compartment Syndrome: a Study Based on Healthy Volunteers
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
