Colorectal Cancer — Interventions to Improve Bowel Cancer Screening Uptake in Ireland: a 2x2 Factorial Trial
Citation(s)
Allison JE, Fraser CG, Halloran SP, Young GP Population screening for colorectal cancer means getting FIT: the past, present, and future of colorectal cancer screening using the fecal immunochemical test for hemoglobin (FIT). Gut Liver. 2014 Mar;8(2):117-30. doi: 10.5009/gnl.2014.8.2.117. Epub 2014 Mar 11. Review.
BowelScreen BowelScreen: Programme Statistical Bulletin 2016 - 2017 [Internet]. 2018 [cited 2019 Oct 29]. Available from: http://www.screeningservice.ie/publications/BowelScreen_statistical_bulletin_2016-2017_FINAL%203_7_19.pdf
Cane J, O'Connor D, Michie S Validation of the theoretical domains framework for use in behaviour change and implementation research. Implement Sci. 2012 Apr 24;7:37. doi: 10.1186/1748-5908-7-37.
Clarke N, Gallagher P, Kearney PM, McNamara D, Sharp L Impact of gender on decisions to participate in faecal immunochemical test-based colorectal cancer screening: a qualitative study. Psychooncology. 2016 Dec;25(12):1456-1462. doi: 10.1002/pon.4085. Epub 2016 Feb 11.
Clarke N, Kearney PM, Gallagher P, McNamara D, O'Morain CA, Sharp L Negative emotions and cancer fatalism are independently associated with uptake of Faecal Immunochemical Test-based colorectal cancer screening: Results from a population-based study. Prev Med. 2021 Apr;145:106430. doi: 10.1016/j.ypmed.2021.106430. Epub 2021 Jan 19.
Clarke N, McNamara D, Kearney PM, O'Morain CA, Shearer N, Sharp L The role of area-level deprivation and gender in participation in population-based faecal immunochemical test (FIT) colorectal cancer screening. Prev Med. 2016 Dec;93:198-203. doi: 10.1016/j.ypmed.2016.10.012. Epub 2016 Oct 18.
Clarke N, Sharp L, O'Leary E, Richardson N A report on the excess burden of cancer among men in the Republic of Ireland. 2013 [cited 2015 Aug 14]; Available from: https://www.lenus.ie/hse/handle/10147/316719
Clarke N, Sharp L, Osborne A, Kearney PM Comparison of uptake of colorectal cancer screening based on fecal immunochemical testing (FIT) in males and females: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):39-47. doi: 10.1158/1055-9965.EPI-14-0774. Epub 2014 Nov 6. Review.
Digby J, McDonald PJ, Strachan JA, Libby G, Steele RJ, Fraser CG Use of a faecal immunochemical test narrows current gaps in uptake for sex, age and deprivation in a bowel cancer screening programme. J Med Screen. 2013 Jun;20(2):80-5. doi: 10.1177/0969141313497197. Epub 2013 Jul 18.
Douma LN, Uiters E, Timmermans DR The Dutch public are positive about the colorectal cancer-screening programme, but is this a well-informed opinion? BMC Public Health. 2016 Nov 29;16(1):1208.
Essink-Bot ML, Dekker E Equal access to colorectal cancer screening. Lancet. 2016 Feb 20;387(10020):724-6. doi: 10.1016/S0140-6736(15)01221-0. Epub 2015 Dec 9.
Hirst Y, Stoffel S, Baio G, McGregor L, von Wagner C Uptake of the English Bowel (Colorectal) Cancer Screening Programme: an update 5 years after the full roll-out. Eur J Cancer. 2018 Nov;103:267-273. doi: 10.1016/j.ejca.2018.07.135. Epub 2018 Sep 7.
Issaka RB, Avila P, Whitaker E, Bent S, Somsouk M Population health interventions to improve colorectal cancer screening by fecal immunochemical tests: A systematic review. Prev Med. 2019 Jan;118:113-121. doi: 10.1016/j.ypmed.2018.10.021. Epub 2018 Oct 24.
Kerrison RS, McGregor LM, Marshall S, Isitt J, Counsell N, Wardle J, von Wagner C Use of a 12 months' self-referral reminder to facilitate uptake of bowel scope (flexible sigmoidoscopy) screening in previous non-responders: a London-based feasibility study. Br J Cancer. 2016 Mar 29;114(7):751-8. doi: 10.1038/bjc.2016.43. Epub 2016 Mar 15.
McNamara D, Leen R, Seng-Lee C, Shearer N, Crotty P, Neary P, Walsh P, Boran G, O'Morain C Sustained participation, colonoscopy uptake and adenoma detection rates over two rounds of the Tallaght-Trinity College colorectal cancer screening programme with the faecal immunological test. Eur J Gastroenterol Hepatol. 2014 Dec;26(12):1415-21. doi: 10.1097/MEG.0000000000000207.
NHS Highland DPH Annual Report 2019 and appendices [Internet]. Scotland; 2019 [cited 2020 Jan 17]. Available from: https://www.nhshighland.scot.nhs.uk/Publications/Documents/DPH-Annual-Report-2019-and-appendices.pdf
Vart G, Banzi R, Minozzi S Comparing participation rates between immunochemical and guaiac faecal occult blood tests: a systematic review and meta-analysis. Prev Med. 2012 Aug;55(2):87-92. doi: 10.1016/j.ypmed.2012.05.006. Epub 2012 May 23. Review.
Wardle J, Robb K, Vernon S, Waller J Screening for prevention and early diagnosis of cancer. Am Psychol. 2015 Feb-Mar;70(2):119-33. doi: 10.1037/a0037357.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.